Vasodilator Properties of Nitroglycerin, Isosorbide Dinitrate and Chlorpromazine during Cardiopulmazine during Cardiopulmonaty Bypass / 대한마취과학회지

In a placebo-controlled trial, we have studied the vasodilator properties of bolus dose of nitroglycerin, isosorbide dinitrate and chlorpromazine in 38 patients during cardiopulmonary bypass with a constant pump flow. Mean arterial pressure and blood volume of the venous reservoir were recorded for 10 min after drug administration to detect changes in arteriolar resistance and venous capacitance, respectively. Nitroglycerin, 2.5 ug/kg, decreased arterial pressure, but the effect lasted for 3 minutes. Chlorpromazine, 0.1 mg/kg, decreased arterial pressure for 9 minutes. Isosorbide dinitrate, 20 ug/kg, had no significant change on arterial pressure. The venous capacitance-increasing effects of nitroglycerin and chlorpromazine were significant for 4 minutes after the bolus. Thereafter the effect of nitroglycerin began to decline, while that of chlorpromazine significantly continued. Isosorbide dinitrate had no significant change on venous reservoir level. The SVR reduction effects of nitroglycerin was significant for 3 minutes, chlorpromazine decreased SVR for over 10 minutes. In conclusion chlorpromazine effect on arterial pressure and venous capacitance was more potent and longer than nitroglycerin and isosorbide dinitrate. Nitroglycerin and chlorpromazine effect on preload and afterload were significant after bolus dose.

Effect of Intravenous Anesthetics on Systemic Vascular Resistance during Cardiopulmanary Bypass / 대한마취과학회지

We have studied the effect of thiopental sodium, propofol, midazolam and ketamine on systemic vascular resistance(SVR) during cardiopulmonary bypass with constant pump flow in 20 patients undergoing elective open heart surgery. SVR decreased about 13(+/-3.42)% of control values after thiopental sodium 4 mg/kg, about 10 (+/-5.30)% of control after propofol 2 mg/kg and about 8(+/-3.72)% of control after midazolam 0.2 mg/kg; it returned to control values about 2 min 30 sec(+/-1 min 20 sec) after administration of thiopental sodium and about 4 min 30 sec(+/-2 min 15 sec) after administration of propofol. It remained under control values after 10 min after administration of midazolam. Ketamine showed no significant changes on SVR. Analysis of variance showed that there were no significant differences in the changes in SVR between the groups. Change of SVR after administration of thiopental sodium did not have statistical significance(P< 0.05).

Effect of the Types of Operation or Agieng on Blood Glucose Changes during Halothane Anesthesia / 대한마취과학회지

The goal of this study was of what change in blood glucose the operation area and ageing made during halothane anesthesia. Sixty patients who were chosen randomly were divided into 4 operation groups according to operation site, that is, nil, surface, abdomen and thorax. Again, each operation group was fractionated into the young(below 40 year old), the middle (from 4l to 60) and the old(above 61). The blood sampling was done at preinduction for control value, 15 min, 30 min, 45 min and 60 min after induction for nil, and 15 min, 30 min, 45 min and 60 min after incision for operation-received groups. The results were as follows; 1) In nil, the young and the middle increased, but the old decreased in blood glucose. 2) In operation-received groups, there was no significance in blood glucose change among 3 age fractions. 3) The blood glucose change was larger in operation-received groups than in nil, more prominent in abdomen and thorax groups than in surface group. 4) The blood glucose of preinduction had no significance among 4 operation groups.