[Effect of the adiantum capillus veneris extract on bax and Bcl2 apoptotic markers of lung modulation in trained rats and exposed to hypoxic stress]

Background: Apoptosis is a type of programmed cell death that occurs by a series of Intercellular messages under Specific conditions

Objective: The aim of present study was investigat role of the Adiantum capillus veneris extract on modulation of Bax and Bcl2 Apoptotic markers of lung in trained rats and exposed to hypoxic stress

Methods: 14 male Wistar rats were sampels of This study, that were Quite healthy and had no disease history [4 weeks old, 72 +/- 9 gr weight] that exposed to hypoxic Environment for 3 weeks after 6 weeks high intensity interval training. Half of the samples were taken 500 ml Adiantum capillus veneris extract Per kilogram of body weight in During exposure to hypoxia environment. Finally, lung tissue was extracted for Immunohistochemical Measurements

Results: Statistical analysis showed that Adiantum capillus veneris extract Consumption for 3 veeks in samples that exposed to hypoxia, Significantly reduced Bax protein Expression of Pulmonary alveolar [P 0.05] and Significantly reduced Bax /Bcl2 Ratio[P

Conclusion: It seems that Adiantum capillus veneris extract, Could possibly modulat Pro-apoptotic and anti-apoptotic proteins expression in pulmonary alveolars that exposed to hypoxic Environment that likely has Considerable effects to Inhibition of lung Pro-apoptotic reactions Due hypoxia

[Effect of swimming during pregnancy on vascular endothelial growth factor level of neonatal rat kidney tissue]

The kidney has a key role in homeostatic regulation. Vascular endothelial growth factor [VEGF] is essential regulator of stimulatory and inhibitory processes for neonatal, post-natal endothelial cell differentiation. This study was done to determine the effect of maternal swimming during pregnancy on VEGF level of kidney in rat pups. In this experimental study, sixteen Wistar rat dams were allocated into interventional swimming and control groups. In the first day of pregnancy, in interventional group, swimming was performed for 30 minutes a day and 5 minutes every day was added until the time of training gradually reached to one hour per workout. Dams swimming endurance training were performed in 5 days per week for three weeks. Pups' kidneys were removed two days after birth and kindney tissue VEGF level was determined using ELISA method. Kidney tissue VEGF level in interventional swimming group [133.13 pg/ml] was significantly increased in compared to controls [48.19 pg/ml] [P<0.05]. Swimming endurance training increases the pups' kidney VEGF level