ABSTRACT
Introduction: acute Urinary Retention [AUR] related to benign prostatic hyperplasia [BPH] is an increasingly prevalent condition in men, and the presenting feature in about 25% of men undergoing prostatectomy
Objective: evaluate the efficacy of sildenafil for treating patients with AUR due lo BPH
Materials and Methods: this is a clinical trial, randomized, double blind study. Eighty patients with AUR related lo BPH randomly assigned to receive either 0.4mg tamsulosine hydrochloride and 25mg sildenafil citrate or 0.4mg tamsulosine hydrochloride and placebo. After 48hours, the catheter was removed and ability to void in each group was assessed. Data were analyzed by SPSS 10 and K 2, T test, P<0.05 was considered significant
Results: differences in age, prostate size and residue was not significant between two groups [p=0.791, p=0.587, p=0.364 respectively]. After catheter removal 22 patients [55%] in placebo group and 32 patients [80%] in sildenafil group voided successfully [p=0.017]. After week 19 men [47.5% ] taking placebo and 28men [70%] taking sildenafil could void yet [p=0.041].The difference 1 between two groups was statically significant [p=0.041]
Conclusion: addition of sildenafil citrate to alpha-blockers is effective in successful voiding after catheter removal for AUR related to BPH. Sildenafil may be recommended for reducing the re-catheterization rate
ABSTRACT
Introduction: Varicocele is an abnormal tortuosity and dilatation of the testicular veins within the spermatic cord. Varicocele is approximately found in 15% of the general population, despite of the high relatively prevalence of varicocele in the general population, and its association with impaired spermatogenesis and steroid genesis, the paucity available of information and majority of studies were centralized on pathophysiology, methods and results of Varicocele reparation. Regarding to the potential inheritance pattern, we desided to perform this study
Objective: Evaluate the hereditary behavior of varicocele through comparison of prevalence of disease in firstdegree relatives of patients with known varicocele and normal healthy kidney donation volunteers
Materials and Methods: This is a cross-sectional study; Sixty-two patients with known varicocele who were admitted for surgery in Razi hospital between September 2005 and October 2006 were enrolled in the study. Their healthy available first -degree relatives [N=88] were asked to refer and examin. A group of 100 men who were refered for voluntary kidney donation were selected as control group and were assessed for varicocele
Results: Among the 88 first -degree relatives of patients with a known varicocele, 40 cases [45.4%] and 11 cases [11%] of 100 men in control group had a clinically palpable varicocele on physical examination. There was a statistically different. Between two groups among the first-degree relatives, 32 cases [55.1%] of 58 brothers, 8 cases [26.6%] of 30 fathers had palpable varicocele
Conclusion: Clinical varicoceles are more prevalent among first-degree relatives [particularly brothers] of patients with known varicoceles and may be an indicator of hereditary behavior of the disease and necessity of screening for male family members
ABSTRACT
To evaluate the efficacy of an alpha-blocker [prazosin] for the treatment of idiopathic oligozoospermia. The study group included 18 infertile men aged 26 to 45 years [with mean age of 35 years] with sperm densities between to 20 x 10[6] sperm/ml, normal serum gonadotropins, testosterone, and prolactin level. Patients were prescribed prazosin - 2mg/d for six months. Semen samples were collected before and three months and six months after therapy. Semen parameters were evaluated before and after the treatment. The Pregnancy Rate [PR] was 27.7%. There were a significant increase in sperm concentration and total-motile sperm count. It appears that an alpha-blocker [prazosin] is a useful drug in the treatment of idiopathic oligospermic males