[Evaluation of serum hepatitis B antibody level in vaccinated children after 14 years in Kashan, Iran]

Hepatitis B vaccination has been conducted in neonates in the routine vaccination in Iran since 1993. This study was carried out to evaluate the serum hepatitis B antibody level in vaccinated children after 14 years in Kashan, Iran. This prospetive cohort study was conducted on 200 fourteen-year-old children which were selected via a simple random sampling method in Kashan, Iran drung 2008-09. This subjects were have been vaccined according to the govermental guildline at 0, 2 and 6 months old. Two ml blood specimens were obtained from children and serum hepatitis B surface antibody [anti-HBs] and hepatitis B core antibody [anti-HBc] were determined by ELISA method. Immunity was interpreted as anti-HBs>/= 10 IU/L. Data were analyzed using SPSS-13, Chi-Square and Fisher's exat tests. 92% girls and 95% boys, totally 187[93.5%] children had serum anti-HBs>/= 10 IU/L. Anti-HBc was positive in 3 [3%] girls and 5[5%] boys, totally 8[4%] which all of them had serum anti-HBS/= 2.5 kg [P<0.05]. The immunity following the complete series [0, 2, 6 months old] of hepatitis B vaccination remained detectable after 14 years

[ gabapentin effect on pain morphin consumption after total abdominal hysterectomy]

Post operative pain is one of the important factors affecting recovery from surgery and anesthesia. Gabapentin is used as an anticonvulsant drug that acts through voltage-dependent calcium channels. In some recent studies, oral gabapentin has been reported to reduce post operative pain and morphin consumption following mastectomy and hysterectomy. The aim of the present study was to determine the effect of gabapentin on postoperative pain after abdominal hysterectomy. In a double-blinded clinical trial design, 50 women aged 35- 50 years old, whom were candidate for hysterectomy referred to Shabih Khani Hospital in 1389, were signed up for the study. Patients received randomly either oral gabapentin 1200 or placebo 1 hr prior to the surgery. Pain was assessed on a visual analogue scale [VAS] at 2, 6, 12, and 24 hr intervals after the operation. Morphine consumption and drug-induced complications such as nausea and vomiting were recorded and compared between the two groups. Factors including age, mean operative time, mean anesthesia time, and BMI were not significantly different between the test and control groups. However, the mean pain scores at 2, 6, 12, and 24 hr after operation were significantly lower in the gabapentin group in comparison to the controls [P<0.0001]. The morphin consumption was also significantly lower in the gabapentin group [P<0.0001]. Furthermore, the average time before the first to walk following the operation was significantly shorter in the gabapentin group [P=0.002]. Preoperative oral gabapentin decreases the pain scores in the postoperative period and lowers the morphine consumption in patients following abdominal hysterectomy

Spirometric standards for healthy Iranians dwelling in the centre of Iran

In order to determining spirometric reference values in healthy, nonsmoker adult subjects, this study was performed on populations dwelling in the centre of Iran, Kashan city. The area was selected as the representative of a less polluted area in Iran, as we intended to exclude possible effects of air pollution on spirometric values. The study was performed on 550 subjects [295 Males, 255 Females] aged 17 to 82 years, randomly selected from the general population, and assessed anthropometrically for age and height by using stepwise regression analysis. The prediction equations were calculated on the basis of age and height for forced vital capacity [FVC], forced expiratory volume in one second [FEV1], and forced expiratory flow during the middle half of the FVC [FEF25-75%].Comparisons with predictions of other Caucasians studies are reported. A Comparative study of FVC and FEV1 values of our subjects, standardized for age and height was much closer to FVC and FEV1 of other studies. The prediction equations [based on age and standing height] for FVC [liters] in males: -5.546 + 0.065 height - 0.027 age; and females -3.214+ 0.046 height - 0.023 age; FEV1 [liters] in males: -2.853 + 0.046 height - 0.029 age; and females: - 2.430 + 0.039 height- 0.024 age; for FEF25-75% in males: + 1.987 + 0.027height - 0.044 age; and females: - 0.769 + 0.037 height - 0.033 age. A comparison between equation from the present study and other available reference data shows that our prediction values were similar to those previously reported. The present regression equations for predicted values of lung function measurements may be regarded as the definitive norms for adult population dwelling in the centre of Iran and will be useful for diagnostic and research purposes