ABSTRACT
Because of the increasing interest in the therapeutic use of triazine derivatives, the effect of 3-hydrazino-5, 6-diphenyl [1, 2, 4]triazine [Triazine I] and 3-hydrazino [1, 2, 4] triazine [5, 6-b] indole [Triazine II] on some parameters of carbohydrate metabolism, were studied in rats. In rats treated with either of the two triazines, serum glucose rose significantly, serum insulin level was significantly reduced, serum lactic dehydrogenase [LDH] activity increased significantly, whereas, serum cirate and muscle glycogen did not change significantly. Liver glycogen content was significantly reduced with triazine I and did not change with triazine II. On the other hand, blood pyruvate level did not change significantly with triazine I, whereas triazine II reduced it. These results suggest that triazine derivatives may interfere with carbohydrate metabolism in rats