ABSTRACT
Diabetes mellitus is the most common disease of the endocrinal glands. Since it is one of the ailments of nephropathic diabetes, so this research aims at the surveying of unbiased stereology [Cavalieri principle] of the extract of Aloe vera leaf on the diabetic rat kidney. At first, 32 male Wistar rats, 140/13 +/- 25/74 gr, were divided into: control, control + extract, diabetic control, diabetic + extract groups. Each group n=8 were divided randomly. IDDM was established by the Intra-Pertoneal injection of 60 mg/kg streptozotocin in two times, control groups. Control + extract and diabetic + extract groups were treated by Aloe vera extract with doses of 70 mg/rat/day. After 30 days, rats left kidneys were excised and fixed by bouin solution. After tissue processing, staining by H and E was carry out, and at the end, with the stereology technique, quantitative information about the cortex, medulla, total kidney and glomeruli volumes was deducted. Statistical results of Anova/Tukey test and T-Test by using of SPSS 11 software showed that the mean of final body weight is increased in control, control + extract and diabetic + extract groups in comparison with diabetic control [p<0/001]. Cortical and total kidney volumes are significantly increased in control + extract, diabetic + extract groups in comparison with diabetic control [p<0/001]. Total glomeruli volume also is increased in control + extract and diabetic + extract groups, in comparison with control and diabetic control. This research shows that Aloe vera extract dose not have an effect on diabetic kidney manifestation during the course of the above treatment