Toxic effect of paroxetine on electroencephalogram, thyroid function and ainino acids in rat

In the present study, the effects of acute and chronic [up to 30 days] treatment with paroxetine on electroencephalogram, amino acids, T[3], T[4], ALT, AST and Urea have been investigated. Furthermore, paroxetine concentrations in different organs of rats at the same time points have been measured. Chronic administration of paroxetine significantly increased ALT, AST activities, Urea, and T[3] levels while reduced T[4] levels. The drug also altered amino acids metabolism in liver and brain. Paroxetine showed EEG changes with pronounced stimulation and produced some dysphoria, sedation and hallucination effects similar to serotonin syndrome drugs