ABSTRACT
Primary squamous cell carcinoma [SCC] of the liver is a very rare entity and to the best of our knowledge only 35 cases have been so far reported worldwide. Squamous cell carcinoma is usually diagnosed in skin, head and neck, respiratory tract, esophagus, cervix, and rectum. However, it can rarely occur in the liver as a primary tumor. It has been reported to be associated with liver cysts, chronic inflammation of biliary ducts, and biliary stones. Primary SCC of the liver has an aggressive behavior and poor prognosis. Herein, we reported a middle-aged lady presented with a hepatic mass. Biopsy of the mass revealed SCC and no primary source, other than the liver itself, could be found despite extensive examinations. That is why the tumor was considered to be a primary occurrence of SCC in the liver