ABSTRACT
Background: Acute ischemic stroke is a potentially treatable condition, if left untreated, lead to mortality and morbidity. This study was conducted to study clinical profile of patients with acute ischemic stroke receiving intravenous thrombolysis (r-TPA-alteplase) and to measure the outcome of thrombolysis.Methods: Retrospective observational study of 54 patients who underwent thrombolysis for acute ischemic stroke at National Medical College, Kolkata over a period of one year.Results: There was statistically significant improvement in NIHSS (p value-0.000) after intravenous thrombolysis.Conclusions: IV thrombolysis is feasible for AIS in governmental hospital in India.
ABSTRACT
Van der Knaap disease is a rare form of leukodystrophy, phenotypically characterized by megalencephaly, early-onset ataxia, pyramidal features, cognitive impairment, with an autosomal recessive inheritence. MRI Brain shows T1 and FLAIR hypointense subcortical cysts in mostly temporal lobes and in fronto-parietal subcortical areas. Authors report a 20 yr. girl with typical features.
ABSTRACT
Ross syndrome is a rare partial dysautonomic syndrome of unknown aetiology, characterized by segmental hypo/ anhidrosis associated with Holmes-Adie syndrome (tonic pupil and hypo/areflexia). The hypohydrosis or anhydrosis is patchy initially, later it becomes segmental or diffuse. This is due to affection of postganglionic cholinergic parasympathetic and sympathetic fibers involvement. There are a very few cases (approximately 50) have been reported in the literature since its original description. Author report a 22 years old male with classical features of Ross syndrome.
ABSTRACT
One of the important challenges of modern drug therapy is the optimization of the pharmacological action of a drug along with the reduction of its toxic side effects in vivo. One response is the use of drug carriers that can provide site specific or targeted drug delivery combined with optimal drug release profiles. Nanoparticulate systems (NPS) as a drug delivery system is an emerging field in medical sciences since they are believed to target the delivery of the drug in cells reduce dose and thus reduce side effects and dose related toxicities.The gastrointestinal tract (GIT) uptake of nanoparticulate systems is nowadays well accepted phenomenon. Uptake of Nanoparticulates from the gut can provide an additional drug administration route with its own pharmacokinetic parameters and specific drug-carrying ability. The drug is transported into the GIT by carriers whose physicochemical characteristics must be taken into account, although the physico-chemical and pharmacological characteristics of the drug remain intact. In this article we concentrate particularly on the translocation of NPS via the lymphatic system, and their use.