Macroscopic Examination of Biopsy Tissue

Gross tissue evaluation of a pathology specimen forms an indispensable but often neglected component for complete pathologic evaluation along with microscopic examination. Macroscopic features are helpful in the differential diagnosis of various cases, which are of challenge. The gross features of the surgical specimen have to be properly examined and documented at the initial setup because once the specimen is dissected and taken for processing it is unsuitable for gross examination. Therefore, the gross or the macroscopic description remains the only document later which can provide an important clue for diagnosis. The purpose of this present article is to provide adequate insight into the gross examination and description of the surgical specimen and to review the macroscopic features of various pathologies.

Odontogenic Tumour Patterns- An Introspective Analysis.

Odontogenic tumours encompass a diverse group of uncommon tumours that are frequently aggressive in their biological behaviour. They comprise 2.4% of all the lesions biopsied in the dental office. Odontogenic tumours have for years been recognized for presenting clinical & histopathological challenges arising from epithelial, ectomesenchymal and/or mesenchymal elements of tooth forming tissues. Understanding of the most common and rare odontogenic tumours will be of great use in their study and clinical management. Histological patterns and sub-patterns are characteristic of particular tumours, hence serve as a proverbial beacon to arrive at a confirmatory histopathological diagnosis. The molecular mechanisms of Epithelial Mesenchymal Interaction have long been studied as a basis for these versatile tumour patterns. Morphogenesis and cell differentiation in the developing tooth are controlled by a series of reciprocal interactions between the epithelial and mesenchymal tissues. In these rare neoplasms, there is lack of information about ectomesenchymal interactions which is involved in the pathogenesis of these tumours. Our paper aims to assess the validity of tumour pattern as a unique prognostic parameter for odontogenic tumours.

Proliferative Verrucous Leukoplakia and Verrucous Carcinoma-A Hybrid Epithelial Tumour

White lesions are relatively frequent in the oral cavity with a prevalence of approximately 24.8%. Among them is oral leukoplakia with a prevalence rate of 0.2–3.6%. There were various debates about the verrucous carcinoma and PVL (proliferative verrucous leukoplakia) being different entities or a part of spectrum at different stages of the disease process. In this article we are reporting a case with coexistence of two different histological features in the form of verrucous carcinoma and PVL of oral cavity with a need to throw some light to understand the pathogenesis of premalignant lesions.