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Rev. méd. Chile ; 135(3): 370-374, mar. 2007. ilus
Article in Spanish | LILACS | ID: lil-456624

ABSTRACT

Gingival enlargement can be an adverse effect of ciclosporine A and nifedipine use. It has a high relapse rate if the drugs are not discontinued. There is a genetic predisposition to the development of this condition and dental biofilm can also play a role. We report a 64 years old male who received a renal allograft and was treated with cyclosporine and nifedipine. He required six surgical interventions for generalized gingival enlargement. After the sixth relapse, the patient was subjected to a periodontal treatment to eliminate the dental biofilm, which decreased the rate of recurrence of gingival enlargement.


Subject(s)
Humans , Male , Middle Aged , Biofilms/drug effects , Calcium Channel Blockers/adverse effects , Cyclosporine/adverse effects , Gingival Hyperplasia/chemically induced , Immunosuppressive Agents/adverse effects , Nifedipine/adverse effects , Biofilms/growth & development , Gingiva/ultrastructure , Recurrence , Severity of Illness Index
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