ABSTRACT
Objective: To investigate the association between serum omentin-1 levels and adverse cardiac events in patients with hypertrophic cardiomyopathy [HCM]
Subjects and Methods: This prospective, observational study included 87 patients with HCM and 50 age- and sex-matched control subjects. Serum omentin-1 and brain natriuretic peptide [BNP] levels were measured in all subjects, using enzyme-linked immunosorbent assay and electrochemiluminescence, respectively. Patients with HCM were divided into 2 groups acaccording to their omentin levels, i.e., low: .291 ng/mL [n = 48] and high: > 291 ng/mL [n = 39]. Cardiac mortality, hospitalization due to heart failure, and implantable cardioverter-defibrillator [ICD] implantation were considered adverse cardiac events. Statistical analysis included uni- and multivariant logistic regression, receiver-operating characteristic [ROC] analysis, and the Kaplan-Meier method
Results: Serum omentin-1 levels were significantly lower in the obstructive [253.9 +/- 41.3 ng/mL] and nonobstructive [301.9 +/- 39.8 ng/mL] HCM groups than in the control group [767.1 +/- 56.4 ng/mL], p < 0.001, respectively. The BNP levels were higher in the obstructive and nonobstructive HCM groups than in the control group [269.5 +/- 220, 241.0 ] 227, and 24.0 +/- 18.9 pg/mL, respectively, p < 0.001]. The Kaplan-Meier analysis indicated that patients with low omentin-1 levels showed a significantly higher [48.2%] 2-year cumulative incidence of overall adverse cardiac events than those with high omentin- 1 levels [16.2%] [log-rank test, p = 0.001]. In the multivariate logistic regression analysis, omentin-1, interventricular septum [IVS] thickness, and male gender were independent predictors of adverse cardiac events in the follow-up
Conclusion: Omentin-1 levels were lower in patients with HCM than in the control group, and this was associated with worse cardiac outcomes
ABSTRACT
Background and Objective: The coronary slow flow phenomenon [CSFP] is a coronary artery disease with a benign course, but its pathological mechanisms are not yet fully understood
The purpose of this controlled study was to investigate the cellular content of blood in patients diagnosed with CSFP and the relationship of this with coronary flow rates
Methods: Selective coronary angiographies of 3368 patients were analyzed to assess Jhromboiysis in Myocardial Infarction [TIMI] frame count [TFC] values. Seventy eight of them had CSFP, and their demographic and laboratory findings were compared with 61 patients with normal coronary flow
Results: Patients' demographic characteristics were similar in both groups. Mean corrected TFC [cTFC] values were significantly elevated in CSFP patients [p<0.001]
Furthermore, hematocrit and hemoglobin values, and eosinophil and basophil counts of the CSFP patients were significantly elevated compared to the values obtained in the control group [p=0.005, p=0.047, p=0.001 and p=0.002, respectively]
The increase observed in hematocrit and eosinophil levels showed significant correlations with increased TFC values [r=0.288 and r=0.217, respectively]
Conclusion: Significant changes have been observed in the cellular composition of blood in patients diagnosed with CSFP as compared to the patients with normal coronary blood flow. The increases in hematocrit levels and in the eosinophil and basophil counts may have direct or indirect effects on the rate of coronary blood flow