Haemodynamic profile of isoflurane versus total intravenous anaesthsia in patients submitted for closed mitral commissurotomy

This study was conducted on 16 patients submitted to closed mitral commissurotomy surgery. They were randomly classified into two groups eight patients each. The first group recieved thiopentone-for induction and isoflourane-vecronium for maintenance The second group received kjtamine-midazolam for induction and then followed by continuous infusion according to a pharmacokinetics based multistepped decreasing regimen. Arterial cannulation and pulmonary artrey catheter were fixed to measure the haemodynamic variables at 5 time points before and during surgery. Data are collected and analysed statistically to compare both groups and record changes during the course of surgery inside each group. The results showed non significant changes between the two groups regarding the haemodynamic parameters recorded, but the systemic vascular resistance [SVR] was significantly increased in the isoflourane group at post-commissurotomy time point. In conclusion, TIVA with ketamine-midazolam can provide a pattern of haemodynamic stability during mitral valve stenosis surgery comparable to that of isoflurane. Concomitant ad-minsteration of midazolam to ketamine according to the regemin used in this study almost neutralized the cardiovascular effects of ketamine

Perianaesthetic blood glucose measurement; evaluation of a rapid method

This study has been planned to evaluate the accuracy of glucometer [Accutrend]. Fourty blood glucose measurements were randomly included in this study. Patients were anaesthetized by different techniques. Blood glucose concentration was measured by both glucometer and the st and ard laboratory glucose-oxidase method [Beckman Autoanalyser]. From the results of this study, blood glucose values measured by glucometer [Accutrend] are always lower than those measured by the st and ard lab glucose oxidase method and the calculated bias value was 17.6 +/- 51.8 and the limits of agreement were wide ranging from 121.2 to -86mg dL-1 which are unaccepted for clinical purposes