ABSTRACT
Cervical-facial radiotherapy causes innumerable sequelae, being systemic or restricted to the oral environment. Theoral mucosa of these patients is profoundly compromised by radiotherapeutic treatment with or without chemotherapy,presenting several complications. Dentifrices containing sodium lauryl sulfate cause damage, as they lead to drynessof the mucosa. The objective of this work was to develop a dentifrice capable of minimizing xerostomia related toa lower abrasive effect, which was intended for hygiene, prevention of caries, control of dental biofilm, and toothsensitivity in cancer patients. The qualitative composition and physicochemical characteristics of ten dentifrices wereanalyzed, which enabled the preparation of the proposed formulation (PF) that was analyzed periodically for 180days. The quantitative analysis of spreadability not only indicated favorable behavior of the PF in relation to thepackaging and storage conditions but also revealed the need to raise the propylene glycol concentration in the PF toavoid the occurrence of syneresis after 60 days. Furthermore, pH data showed that the PF is compatible with the pHof oral homeostasis thus avoiding the occurrence of dental demineralization. It is suggested that the PF has a singularcomposition and physicochemical quality to be used as a suitable dentifrice for patients undergoing anticancer therapy
ABSTRACT
A incidência da constipação intestinal está frequentemente associada à dieta inadequada e sedentarismo. Acomete indivíduos em qualquer momento da vida. O objetivo deste presente trabalho foi relacionar os medicamentos fitoterápicos atualmente utilizados no tratamento da constipação crônica, apresentando seus mecanismos de ação e seus efeitos adversos. A metodologia empregada baseou-se na pesquisa em base de dados como Scielo, Science Direct, Medline. Os laxantes utilizados clinicamente estão divididos farmacologicamente em 5 tipos, no entanto somente em 2 dessas classes se encontram representantes fitoterápicos: laxativos expansores do bolo fecal e laxativos irritantes ou estimulantes. A utilização de laxantes é produzir evacuações de boa aparência e bem hidratadas, reduzindo os sintomas da constipação crônica.
The incidence of constipation is frequently associated with an inadequate diet and a sedentary lifestyle. It affects individuals at any time of life. The objective of this study was to relate herbal medicines currently used to treat chronic constipation, presenting its action mechanisms and adverse effects. The methodology used was based on research in databases such as Scielo, Science Direct and Medline. The laxative clinically used are pharmacologically divided into five groups; however, only in two of these groups there are herbal medicine representatives: laxatives that expand the stool and irritant or stimulant laxatives. Laxatives are used to produce good and well-hydrated bowel movements, reducing the symptoms of chronic constipation.