ABSTRACT
Gingivitis is an inflammation of dental protective tissues and biofilm accumulation is the main etiologic factor of this disease. Due to the antimicrobial and anti-inflammatory actions shown by Ocimum gratissimum (OCG), this study aimed at evaluating the antiplaque and antigingivitis effect of 3% OCG gel in human gingivitis. Thirty volunteers were selected and subdivided in 2 groups (n=15): control (placebo gel+brushing), and test (3% OCG gel+brushing). All participants received mouth guards to apply the gel 3 times/day during 15 days. Visible Plaque Index (VPI= mean±sd %), Turesky Index (TUR= mean scores±sd) and Gingival bleeding Index (GI= mean±sd %) were performed on days 0 and 15. All the individuals, with mean age of 21.8 years, being 50% females, completed the study. In both groups, control and test, there was a reduction (p<0.05) on VPI of 51.9% and 65.1%, respectively, when compared to each respective baseline. Test showed lower VPI (p<0.05) when compared to control. TUR index corroborated VPI findings. Both experimental groups presented a decrease by 68.4% when compared to its respective baseline. Control and test groups showed reduction on GI of 59.38% and 80.9%, respectively, when compared to baseline. A greater reduction was observed in the use of 3% gel when compared to control (p<0.05). The present study indicates that 3% OCG gel associated to brushing showed antiplaque and antigingivitis effect, being important as an adjuvant to plaque-induced gingivitis treatment
Subject(s)
Gingivitis , Dental PlaqueABSTRACT
BACKGROUND AND OBJECTIVES: Stimulations with formalin in the orofacial region can be related to transient or subacute nociceptive activity and behavioral changes. The evaluation of behavioral changes induced by persistent or chronic irritating nociceptive substance has not yet been described.METHOD: Complete Freund's Adjuvant (CFA) was injected in the temporomandibular joint (TMJ) region of rats and analyzed comparing it to the groups treated with saline and 2.5% formalin. In addition, behaviors such as grooming, freezing, rest/sleeping and chewing-like were electronically observed and quantified.RESULTS: It was shown that the chewing-like behavior was significantly increased and that it was inhibited by indometacin (5 mg/kg) and morphine (4 mg/kg). CONCLUSION: These results suggest that chewing-like may be a possible behavior of persistent or chronic orofacial pain, and may be a tool for clinical-pharmacological studies.
JUSTIFICATIVA E OBJETIVOS: Estímulos com formalina na região orofacial podem estar relacionados com a atividade nociceptiva e as alterações comportamentais transitórias ou subagudas. A avaliação de comportamentos sob ação de substância irritante nociceptiva persistente e crônica ainda não foi descrita.MÉTODO: Foi feita injeção de adjuvante completo de Freund (ACF) na região da articulação temporomandibular (ATM) de ratos e foi analisada comparando-a com os grupos tratados com salina e formalina a 2,5%. Além disso, foram observados e quantificados eletronicamente os comportamentos grooming, freezing, rest/sleeping e chewing-like (mastigação). RESULTADOS: Observou-se que o comportamento mastigação (chewing-like) estava significativamente aumentado e que ele foi inibido pela indometacina (5 mg/kg) e morfina (4 mg/kg).CONCLUSÃO: Esses resultados sugerem ser o chewing-like um possível comportamento de dor orofacial persistente, oferecendo-se como instrumento para análise clínico-farmacológica