Drug interaction with radiopharmaceuticals: effect on the labeling of red blood cells with technetium-99m and on the bioavailability of radiopharmaceuticals

The evidence that natural and synthetic drugs can affect radiolabeling or bioavailability of radiopharmaceuticals in setting of nuclear medicine clinic is already known. However, this drug interaction with radiopharmaceuticals (DIR) is not completely understood. Several authors have described the effect of drugs on the labeling of blood elements with technetium-99m (99mTc) and on the biodistribution of radiopharmaceuticals. When the DIR is known, if desirable or undesirable, the natural consequence is a correct diagnosis. However, when it is unknown, it is undesirable and the consequences are the possibility of misdiagnosis and/or the repetition of the examination with an increase of radiation dose to the patient. The possible explanation to the appearance of DIR are (a) radiopharmaceutical modification, (b) alteration of the labeling efficiency of the radiopharmaceutical, (c) modification of the target, (d) modification of no target and/or the (e) alteration of the binding of the radiopharmaceutical on the blood proteins. The effect of drugs on the labeling of blood elements with 99mTc might be explained by (i) a direct inhibition (chelating action) of the stannous and pertechnetate ions, (ii) damage induced in the plasma membrane, (iii) competition of the cited ions for the same binding sites, (iv) possible generation of reactive oxygen species that could oxidize the stannous ion and/or (v) direct oxidation of the stannous ion. In conclusion, the development of biological models to study the DIR is highly relevant

Criterios para el diagnostico de aspergilosis y candidosis sistemica / Criteria for the diagnosis of aspergillosis and systemic candidosis

Con objeto de ayudar al diagnóstico de aspergilosis y candidosis sistemíca, se estudiaron 253 casos de pacientes con afecciones respiratorias por medio de pruebas inmunológicas. Basados en los resultados, se sugiere el siguiente criterio para su diagnóstico: características clínicas del paciente, cultivos seriados positivos de muestras biológicas, histopatología sugestiva (presencia del hongo en tejido), pruebas inmunológicas seriadas con títulos elevados y resultados similares en precipitinas, aglutininas y reacción de fijación de complemento