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Chinese Journal of Pathology ; (12): 111-114, 2003.
Article in Chinese | WPRIM | ID: wpr-255354

ABSTRACT

<p><b>OBJECTIVE</b>To study the histogenesis and pathological characteristics of gastrointestinal stromal tumors (GIST) and GIST type stromal tumor (ST) beyond the gastrointestinal tract.</p><p><b>METHODS</b>A retrospective study was carried out on leiomyoma, leiomyosarcoma and neurilemoma (46 cases in gastrointestinal tract and l3 cases in urinary tract and perineal area). 4 antibodies (CD117, CD34, SMA, S-100) were used for immunohistochemical staining.</p><p><b>RESULTS</b>Among 45 cases of GIST, the positive rate of CD117 and CD34 was 93.3% and 88.9% respectively. Among 12 cases of GIST type ST beyond the gastrointestinal tract, the positive rate of CD117 and CD34 was 83.3% and 75.0% respectively. In 2 cases (1 in gastrointestinal tract) of leiomyomas, both CD117 and CD 34 were negative in tumor cells, while SMA was extensively positive.</p><p><b>CONCLUSIONS</b>CD117 and CD34 positivity are the most valuable factors in diagnosing ST. Both GIST and GIST type ST beyond the gastrointestinal tract are considered originating from a proto-interstitial stem cell with disoriented differentiation.</p>


Subject(s)
Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Actins , Antigens, CD34 , Biomarkers, Tumor , Gastrointestinal Stromal Tumors , Chemistry , Pathology , Immunohistochemistry , Leiomyoma , Chemistry , Pathology , Leiomyosarcoma , Chemistry , Pathology , Neurilemmoma , Chemistry , Pathology , Pelvic Neoplasms , Chemistry , Pathology , Perineum , Proto-Oncogene Proteins c-kit , Retrospective Studies , S100 Proteins , Urologic Neoplasms , Chemistry , Pathology
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