ABSTRACT
<p><b>OBJECTIVE</b>To explore the clinical effect of the multidisciplinary treatment combined orthodontics with implant prosthodontics for cases of dentition defect with malocclusion.</p><p><b>METHODS</b>Seventeen cases of dentition defect with malocclusion were observed. All the cases accepted the orthodontic treatment in order to establish normal occlusion and achieve adequate space for implants. After that, the missing teeth were replaced by implant-supported denture. The clinical effect was evaluated by clinical examination and radiographic examination.</p><p><b>RESULTS</b>Satisfactory esthetic and functional results were achieved for all the cases. The follow-up time ranged from 12 months to 48 months. 76 implants were inserted totally. Two of them were extracted due to peri-implantitis. However, the other 74 implants were stable with an average loading time of 32 months. The cumulative survival rate was 97.4%.</p><p><b>CONCLUSION</b>The multidisciplinary approach combined orthodontics with implant prosthodontics was an effective treatment option for cases of dentiton defect with malocclusion.</p>