An open label efficacy study of topical imiquimod 5% cream in the treatment of verruca vulgaris and verruca plana in Filipinos

BACKGROUND: Verrucae or warts, are benign epithelial growths caused by human papillomavirus (HPV) infection of the skin. They are unsightly and may affect a patient's quality of life, causing social embarrassment, discomfort, pain, and interference in certain activities. OBJECTIVE: To evaluate the efficacy and safety of imiquimod 5 percent cream for sixteen weeks in the treatment of verruca vulgaris and verruca plana in an open-label trial involving healthy immunocompetent Filipino patients of the Dermatology out-patient clinic of the Philippine General Hospital. METHODS: Imiquimod 5 percent cream was self-administered by patients with verruca vulgaris or verruca plana on their lesions, nightly for 16 weeks. Follow-up was done every two weeks to determine any change in size over time. Side effects were recorded. RESULTS: Complete clearance was seen in 31.8% of verruca vulgaris cases, with improvement seen in 59 percent of cases. Shorter duration of lesions was associated with clearance. Complete clearance was seen in only 1 out of 8 patients with verruca plana treated. Minor side effects were reported. CONCLUSION: Topical imiquimod 5 percent cream is a safe, well-tolerated, painless, convenient, patient-applied route which may be a preferred alternative treatment for verruca vulgaris.

Reemplazo total de cadera - Hospital Dr. Darío Contreras, 1988-1992 / Hip prosthesis - Hospital Dr. Dario Contreras; 1988-1992

Se realizó un estudio descriptivo de reemplazo total de cadera en el Hospital Dr. Darío Contreras, Santo Domingo, República Dominicana, durante el período 1988-1992. El estudio consistió en la revisión de los expedientes clínicos de los pacientes intervenidos a reemplazo total de cadera, para determinar su edad, sexo, causa etiológica y movimientos articulares. De los 27 casos encontrados el grupo de edad de más incidencia es 61-70 años, con 9 casos (33.3 por ciento ), el sexo femenino 17 casos (62.9), la causa etiológica más frecuente es osteoartritis primaria con 11 casos (40.7 por ciento ) y en los movimientos articulares hubo un aumento después de la cirugía, en especial en la dislocación traumática y fractura de cuello de fémur que casi se logró todos sus movimientos. En función de los resultados, recomendamos medidas preventivas