ABSTRACT
OBJECTIVE: Noonan syndrome is a multiple congenital anomaly syndrome, and bleeding diathesis is considered part of the clinical findings. The purpose of this study was to determine the frequency of hemostatic abnormalities in a group of Noonan syndrome patients. METHOD: We studied 30 patients with clinical diagnosis of Noonan syndrome regarding their hemostatic status consisting of bleeding time, prothrombin time, activated partial thromboplastin time and thrombin time tests, a platelet count, and a quantitative determination of factor XI. RESULTS: An abnormal laboratory result was observed in 9 patients (30 percent). Although coagulation-factor deficiencies, especially factor XI deficiency, were the most common hematological findings, we also observed abnormalities of platelet count and function in our screening. CONCLUSIONS: Hemostatic abnormalities are found with some frequency in Noonan syndrome patients (30 percent in our sample). Therefore, we emphasize the importance of a more extensive hematological investigation in these patients, especially prior to an invasive procedure, which is required with some frequency in this disorder
Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Child , Adolescent , Adult , Blood Coagulation Disorders , Noonan Syndrome/blood , Blood Coagulation , Factor XI Deficiency , Hematologic Tests , Hemorrhagic Disorders , Noonan Syndrome/complicationsABSTRACT
Os autores relatan um caso de síndrome de Regressäo Caudal associado ao diabetes materno pós-pancreatectomia. Säo apresentados dados clínicos, laboratoriais e radiológicos do caso, revisäo da literatura e discutidos os aspectos etiológicos da síndrome. Trata-se do 1§ caso da literatura de SRC associado com diabetes pós-pancreatectomia
Subject(s)
Infant, Newborn , Humans , Male , Diabetes Mellitus/complications , Pancreatectomy/adverse effects , Sacrococcygeal Region/abnormalitiesABSTRACT
Os autores descrevem as caracterisiticas de organizacao e operacionalizacao de um atendimento multiprofissional ao paciente com fibrose cistica. Salientam o valor da abordegem global do paciente por profissionais familiarizados com a molestia, possibilitando uma acao terapeutica mais adequada e completa
Subject(s)
Cystic Fibrosis , Patient Care Team , Professional-Family RelationsABSTRACT
Os autores apresentam um caso de sindrome de Patau, diagnosticado clinicamente e com confirmacao atraves do cariotipo.A necropsia verificou-se alteracoes compativeis com o diagnostico de infeccao congenita de etiologia nao determinada: havia antecedentes de lues materna. Discute-se a correlacao entre os dados clinicos e os achados anatomo-patologicos indicativos de infeccao congenita
Subject(s)
Infant, Newborn , Humans , Female , Chromosome Aberrations , Chromosomes, Human, 13-15 , TrisomyABSTRACT
Os autores descrevem um caso de sindrome de Kartagener e fazem comentarios sobre o quadro clinico, etiopatogenia, diagnostico e tratamento dessa sindrome