ABSTRACT
Background:Implantology is a very significant branch of dentistry that deals with the rehabilitation of edentulous patients. Thus, knowledge of anatomical variations of related neurovascular structures such as the nasopalatine canal is essential. Aim:The aim of study was to determine the form, length, and diameter of the nasopalatine canal using CBCT. Materials and Methods:In this retrospective study, images were archived from CBCTunit and visualized using Romexis software. The nasopalatine canals of 50 patients between the age range of 18-59years were analyzed. The shape of the nasopalatine canal, length of the nasopalatine canal and the diameter of incisive foramen were assessed in sagittal and coronal section. The width of labial and palatal alveolar bone around the canal and inclination of the nasopalatine canal to hard palate were evaluated. Statistics: (1) if there is any relation between the gender and the assessed parameters (2) if there is any relation between edentulous and partially edentulous patients with the assessed parameters.Results:The most common shape of the nasopalatine canal was cylindrical. The average length of the nasopalatine canal was 12.14±2.41 mm and the average diameter of incisive foramen 3.45±0.84 mm anteroposteriorly and 3.77±0.94mm mediolaterally. The average inclination of the nasopalatine canal to hard palate was 119.93±9.73°Conclusion:This study highlights the variations seen in the nasopalatine canal. The close vicinity of nasopalatine canal and implant can lead to sensory disturbances and damage of the tissues. Thus, a thorough knowledge before the surgical - implant procedure using cone beam computed tomography seems beneficial.
ABSTRACT
Variety of substances such as tobacco, UV radiation, infrared rays, X-radiations, and chemicals on oral induction results in chromosomal aberrations and production of micronucleus (MN). Among them, tobacco-specific nitrosamines are potent mutagenic agents causing oral cancer. Objective: The objective of the study is to compare the genotoxicity in buccal mucosal cells, i.e. the MN count of all groups and to find the incidence of micronucleated cells (MNCs) in accordance to duration and frequency of tobacco usage and timing of contact of tobacco in the oral mucosa. Materials and Methods: Individuals without any oral diseases were divided into 3 groups having 25 in each group: smoking, chewing, and control. Smears were made from buccal exfoliated cells and stained with DNA-specific Feulgen stain. Frequency on MNC per 500 cells was assessed with one-way ANOVA and Tukey HSD multiple comparisons test and mean rank with Kruskal–Wallis test. Results: The mean micronucleus MN revealed that chewers had 8.00, smokers had 7.20 and controls had 0.4. The ANOVA test for mean frequency of micronucleated cell MNC revealed High significance (<0.001) for between groups comparison. The mean rank by Kruskal Wallis test revealed the MNC increases as the duration and frequency of habit increases. An increase in MNC in accordance to time of contact with buccal mucosa increases as the duration and time increases. Conclusion: Estimation of MN serve as an indicator of genetic damage and points that tobacco in chewing form induce genotoxic effect. This is studied in an easily accessible tissue- buccal mucosa in a non invasive manner.
ABSTRACT
The environment of oral cavity provides a large surface area for the delivery of drugs bypassing the first pass metabolism in the liver. Hence, the oral cavity is being targeted for providing quicker delivery of drugs for immediate action. However, oral delivery system in the form of tablets/ capsules needs modifications in elderly, children, and unconscious patients because of the fear of choking and aspiration. To overcome these problems much research is being undertaken to develop oral bio dissolving films as an alternative to tablets. The objective of the article was to provide an overview of the composition, advantages and disadvantages, and uses of bio dissolving films in the field of medicine and dentistry.