ABSTRACT
Background: Lignocaine and bupivacaine are still the largely used local anaesthetics in the present day. Here, we are presenting a comparative study of single dose extradural analgesia with Bupivacaine and Lignocaine with adrenaline.Methods: The study was carried out in 60 healthy subjects posted for lower abdominal, pelvic, perineal and lower limb surgeries. They were randomly divided into 2 groups. Group I and Group II. Group I (N=30): Received 20ml of 1.5% Lignocaine with adrenaline 1:200000. Group II (N=30): Received 20ml of 0.5% Bupivacaine. Results: The mean times (with standard times) been extradural injection and onset of analgesia indicate that Lignocaine had a significantly quicker onset of action. However, it is evident from figure that for both the drugs about 50% of patients showed a latency of 6-10 min. Intra operative complications like hypotension, drowsiness, nausea and vomiting and post-operative complications like headache, back ache, nausea ,vomiting, retention of urine and neurological sequelae were noted. Conclusion: Lignocaine with adrenaline had a significantly quicker onset of action. Duration of analgesia produced by Bupivacaine was found to be significantly longer than that produced by Lignocaine with adrenaline.