ABSTRACT
Introduction: In the 21st Century,a large proportion of India’s population belongs to the younger age groupthat’s why called Young India. Before being diagnosed as diabetic, the individual goes through the pre-diabetic period or impaired glucose tolerance phase for almost 4- 5 years which includes acute episodesof hyperglycemia and hypoglycemia. These acute episodes may lead to micro-vascular diseases resultingin deficits in cardiorespiratory endurance and neurophysiological variables. Targeting young Type 2 DiabetesMellitus (T2DM) patients with exercise therapy may delay the onset and complications and provide them witha better quality of life. Therefore, the present study has assessed, in a randomized manner, the impact ofexercise therapy on cardiorespiratory endurance and neurophysiological functions in young adults of agegroup 20-45 years with T2DM.Objectives: To study the effects of six months structured exercise therapy on cardiorespiratory enduranceand neurophysiological variables in young adults of age 20-45 years with newly diagnosed T2DM on dietarycontrol and anti-diabetic drug of age groupMaterial & Methods: The study was conducted in the Research Laboratory, Department of Physiology onnewly diagnosed asymptomatic patients with type 2 diabetes mellitus of age group 20-45 years. Studyparticipants were recruited from the OPD, Department of Medicine, KLE’s Dr. Prabhakar Kore Hospital andResearch Centre. Recruitment started from the period of April 2017 ended in October 2018 Ethical approvalwas obtained from the institutional ethical committee. Written Informed consent was obtained from allparticipants. The patients were enrolled as per inclusion criteria and then randomly divided into diabeticcontrols and Interventional group. The interventional group was given six months of structured exerciseprogram consisting of aerobic and resistance exercises. The primary study variables were Cardio-respiratoryEndurance variables viz; Physical Fitness Index (PFI) and Maximal oxygen uptake (VO2 maximum) andNeuro- Physiological Variables viz; Nerve Conduction Velocity (NCV) and Audio-Visual Reaction Time (ARTand VRT). The data were collected at baseline and 6th months for both groups and 2nd, 4th month for theinterventional group.
ABSTRACT
Cadmium is one among the most environmental pollutants that affects many organs like kidney, liver and testis. The present study was aimed to assess the simultaneous effects of black tea extracts (BTE) on cadmium chloride induced alterations in lipid profile and liver histology. Adult rats were divided into four groups (n=6/group), group I (normal saline), group II (CdCl2, 1.0 mg/kg, b.wt; i.p), group III (black tea extract, 2.5 gm tea leaf/dl of water that is 2.5% of aqueous BTE) and group IV (cadmium chloride + BTE). Cadmium chloride intoxicated rats showed significant increase in serum total cholesterol, triglycerides, and low density lipoprotein-cholesterol and there is a significant decrease in the serum high density lipoproteincholesterol. In the liver, cadmium chloride showed changes in normal architecture, swollen hepatocytes, kupffer cells hyperplasia, dilation and congestion of central vein. Oral administration of black tea extracts with cadmium chloride significantly improves lipid profile and liver architecture as compared to the cadmium chloride group. The results indicate that BTE is beneficial in preventing cadmium-induced lipid alterations and hepatocellular damage.