ABSTRACT
Lipid profile of Type II Diabetes patients was determined before and after treatment. The study was carried out on 180 [Male/Female: 91/89] treated patients who were registered in Chittagong Diabetic Hospital and 80 [Male/Female: 42/38] newly diagnosed diabetic patients who were selected randomly. 40 [Male/Female: 20/20] non-diabetic healthy subjects were selected for control. All the subjects included in this study were between the age of 40-70 years. In the study, fasting plasma glucose [FPG], serum total cholesterol [TG], serum triglyceride [TG], high density lipoprotein-Cholesterol [HDL-C] were measured. Low density lipoprotein-Cholesterol [LDL-C] was also determined [using Friedwald's formula]. When the lipid profiles of untreated diabetic patients were compared with the control, an increase in TC, HDL-C, LDL-C and TG were found in the former. The increase in TC and LDL-C was highly significant [p<0.001], increase in TG was found significant [p<0.005] whereas increase in HDL-C was not significant. When the lipid profile of treated patients was compared with the untreated patients, decrease in TC, TG and LDL-C in the former patients was found as highly significant [p<0.001] for all parameters, whereas, decrease in HDL-C was found to be less significant. In untreated Type II Diabetes Mcllitus, significant positive correlations were found between fasting plasma glucose [FPG] and [a] TC [r = + 0.01, p<0.0l], [b] TG [r = + 0.07, p<0.01], [c] LDL-C [r = + 0.04, p<0.01] whereas, no significant correlation was found between glucose and HDL-C concentrations. In Type II Diabetes Mellitus, subjects, after treatment, significant positive correlations were also found between fasting plasma glucose and [a] TC [r =+0.21, p<0.01], [b] TG [r = + 0.26, p<0.01], [c] LDL-C [r = + 0.19, p<0.01], whereas no significant correlation was found between glucose and HDL-C concentrations. It was evident from this study that lipid abnormalities exist in Type II Diabetes and significant improvement against lipid abnormalities occur after treatment. Lipid abnormalities were related to glycaemic control