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Mem. Inst. Oswaldo Cruz ; 95(3): 367-73, May-Jun. 2000. tab
Article in English | LILACS | ID: lil-258191

ABSTRACT

In this study, we screened sixty medicinal plant species from the Brazilian savanna ("cerrado") that could contain useful compounds for the control of tropical diseases. The plant selection was based on existing ethnobotanic information and interviews with local healers. Plant extracts were screened for: (a) molluscicidal activity against Biomphalaria glabrata, (b) toxicity to brine shrimp (Artemia salina L.), (c) antifungal activity in the bioautographic assay with Cladosporium sphaerospermum and (d) antibacterial activity in the agar diffusion assay against Staphylococcus aureus, Escherichia coli, Bacillus cereus and Pseudomonas aeruginosa. Forty-two species afforded extracts that showed some degree of activity in one or more of these bioassays.


Subject(s)
Animals , Bacterial Infections/prevention & control , Mycoses/prevention & control , Parasitic Diseases/prevention & control , Plants, Medicinal/adverse effects , Artemia/drug effects , Biomphalaria/drug effects , Brazil , Cladosporium/drug effects , Gram-Negative Bacteria/drug effects , Gram-Positive Bacteria/drug effects , Plant Extracts
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