ABSTRACT
When nasopharyngeal secretions from 171 Australian Aboriginal children hospitalized with acute lower respiratory tract infections (ALRI) were cultured selectively for Streptococcus pneumoniae and Haemophilus influenzae, 136 (79.5%) and 151 (88.3%) children yielded 166 and 254 isolates of S. pneumoniae and H. influenzae, respectively. In colonized subjects multiple populations of S. pneumoniae (20% of carriage-positive patients) and H. influenzae (55%) were common. Pneumococci belonging to 27 types or groups were identified. H. influenzae serotype b colonized 16.4% of all children studied. More than one half of 152 children tested were excreting antibiotics at the time of admission to hospital. Significantly fewer children with serum antibiotic residues were colonized with S. pneumoniae than were antibiotic free children. Antibiotic usage had no measurable impact on the isolation rate of H. influenzae.
Subject(s)
Acute Disease , Anti-Bacterial Agents/blood , Carrier State/blood , Child , Child, Preschool , Racial Groups , Drug Monitoring , Drug Residues , Drug Utilization , Female , Haemophilus Infections/blood , Haemophilus influenzae/classification , Hospitalization , Humans , Infant , Infant, Newborn , Infection Control , Male , Nasopharynx/microbiology , Native Hawaiian or Other Pacific Islander , Pneumococcal Infections/blood , Respiratory Tract Infections/blood , Serotyping , Streptococcus pneumoniae/classificationABSTRACT
Nasal secretions from Papua New Guinea children were cultured using selective agents, to determine the prevalence of multiple colonization for both S. pneumoniae and H. influenzae. 29.5% of 156 and 53% of 93 carriage positive subjects harbored more than one type of S. pneumoniae and H. influenzae respectively. Of 95 strains of pneumococci isolated from multiply colonized children, 40% were relatively resistant to benzylpenicillin. In more than one half of the children in this group both penicillin sensitive and resistant serotypes coexisted. Significantly more penicillin resistant pneumococci were isolated from children with ready access to primary and regional health care services. Among H. influenzae the prevalence of multiple isolations due to nonencapsulated variants only, and encapsulated plus nonencapsulated organisms was similar. The commonest biotypes were types I, II, III and V, and each was similarly associated with multiple carriage.