ABSTRACT
The mucosa associated lymphoid tissue regulates and coordinates immune responses against mucosal pathogens. Mucosal tissues are the major targets exposed to HIV during transmission. In this paper we describe in vitro models of HIV mucosal infection using human explants to investigate target cells within this tissue.
Subject(s)
Adult , Female , Humans , Male , Cervix Uteri , In Vitro Techniques , HIV Infections/immunology , Intestinal Mucosa , Lymphoid Tissue , Immunity, Mucosal , Mucous MembraneABSTRACT
The gut associated lymphoid tissue is responsible for specific responses to intestinal antigens. During HIV infection, mucosal immune deficiency may account for the gastrointestinal infections. In this review we describe the humoral and cellular mucosal immune responses in normal and HIV-infected subjects.
Subject(s)
Humans , Digestive System , HIV Infections/immunology , Antibody Formation , CD4-Positive T-Lymphocytes , Digestive System , Immunity, Mucosal , Immunoglobulin A , Immunoglobulin A, Secretory , Immunoglobulin G , Intestinal Mucosa , Lymphoid Tissue , Gastric Mucosa/immunology , Gastric Mucosa/virologyABSTRACT
The febrile response to a standard dose of triple (DPT) vaccine was assessed in sixteen malnourished children before and after recovery. The increase in temperature was significantly lower in the malnourished children (p < 0.005)