ABSTRACT
A triagem sorológica, bem como a determinação de alguns antígenos sanguíneos são estratégias imprescindíveis para se evitar a transmissão de agentes infecciosos e asreações transfusionais. O objetivo deste estudo é avaliar o perfil epidemiológico, hematológico e imunossorológico entre doadores de sangue do Hemocentro Regional de Cruz Alta durante o ano de 2007. O estudo retrospectivo foi realizado através das fichas de triagem clínica e do banco de dados do Hemocentro. Dentre 3.512 doadores analisados, 172 (4,9%) apresentaram anti-HBc reagente, 51 (1,45%) apresentaram sorologia positivapara HIV, 40 (1,13%) resultados reagentes para o HBsAg, 25 (0,71%) para a Doença de Chagas e 21 (0,60%) para hepatite C. O tipo sanguíneo O positivo foi predominante em44,54% das doações, seguido pelo A positivo (29,95%), O negativo (10,53%), B positivo (6,47%) e, em menor frequência, os tipos A negativo (4,49%), AB positivo (1,97%), Bnegativo (1,18%) e AB negativo (0,78%). Os dados obtidos evidenciaram uma baixa taxade descarte quando comparados a estudos anteriores, demonstrando um aumento da qualidade do sangue transfundido, pois a taxa de descarte de bolsas não representa apenas a prevalência de uma determinada infecção na população de doadores, mas,principalmente, a qualidade do sangue e hemocomponentes disponibilizados para transfusão.
Subject(s)
Humans , Male , Female , Blood , Blood Donors , Blood Transfusion , Communicable Diseases , Donor Selection , Hemotherapy Service , Plastic Bags for Blood Preservation , Quality Control , Cross-Sectional Studies , Epidemiology, Descriptive , Retrospective StudiesABSTRACT
As there was not any data on Chlamydia pneumoniae (TWAR) infections in Brazil so far, a prospective cohort study of adult patients hospitalized due to CAP was carried out for one year in a Brazilian university general hospital to detect the incidence of CAP by Chlamydophila pneumoniae (TWAR) for one year. During a whole year 645 consecutive patients hospitalized due to an initial presumptive diagnosis of respiratory diseases by ICD-10 (J00-J99), excluding upper respiratory diseases, were screened; 59 consecutive patients with CAP were diagnosed. They had determinations of serum antibodies to C. pneumoniae by microimmunofluorescence at the Infectious Diseases Laboratory of University of Louisville (KY, USA); 37 patients (63.8 percent) had seroreactivity to TWAR antigens, from which 23 (39.6 percent) had previous infection; 3 patients (5.2 percent) were diagnosed with CAP by TWAR and got cured. The incidence of TWAR CAP in our hospital by seroconversion was 5.2 percent. Our incidence of 5.2 percent is probably underestimated since TWAR culture was not available; we suggest that Real-Time PCR be used along with other diagnostic methods in future studies to detect the actual incidence of TWAR CAP. We propose that the serological criterion of IgM >1:16 alone to the diagnosis of acute infection by TWAR are discontinued due a lack of specificity.