Low-dose versus standard-dose intravenous alteplase for acute ischemic stroke:comparison of efficacy and safety / 国际脑血管病杂志

Objective To investigate the efficacy and safety of low-dose and standard-dose intravenous alteplase for acute ischemic stroke. Methods The patients with acute ischemic stroke treated with intravenous alteplase from August 2012 to January 2016 were analyzed retrospectively. According to the dosage of the drug, the patients were divided into either a low-dose group (0. 6-0. 8 mg/kg) or a standard-dose group (0. 9 mg/kg). The efficacy was evaluated with the modified Rankin Scale (mRS) at 90 days, and a favorable functional outcome was defined as mRS 0-1. The safety was evaluated by the mortality at 90 days and the incidence of symptomatic intracerebral hemorrhage (SICH) within 7 d after onset. Results A total of 790 patients were enrolled, including 612 in the low-dose group and 178 in the standard-dose group. There was no significant difference in each baseline clinical data between the 2 groups. Compared with the standard-dose group, there was no significant difference in the good outcome rate of the small-dose group at day 90 (35. 6% vs. 37. 6% ; χ2 = 0. 872, P = 0. 35) and mortality (5. 1% vs. 6. 2% ;χ2 = 2. 173, P = 0. 14), but the incidence of SICH was significantly lower (1. 8% vs. 5. 1% ; χ2 = 5. 875, P =0. 015). Conclusion The efficacy of low-dose intravenous alteplase for acute ischemic stroke is equivalent to the standard-dose and the safety is better.

Biocompatibility of skin biological dressings / 中国组织工程研究

Skin can maintain homeostasis and prevent from microorganisms, the loss of skin barrier may be related to many local or general infections after trauma. Biological dressing can seal trauma wound as soon as possible, reduce the risk of infections resulted from pathogenic bacteria on trauma wound, and increase the survival rate of severe patients. Biological dressing is a hot topic in the application researches about the healing of skin trauma wound. An ideal biological dressing is satisfactory in histocompatibility, permeability, gas permeation, and mechanical function. It can control and absorb the effusion on trauma wound, prohibit bacterial invasion and induce bacteriostasis, protect new tissues and facilitate trauma healing, so as to provide a micro-wet, micro acid and hypoxic environment for the trauma. At present, the biological dressings for the skin trauma mainly include pigskin, amnion, collagen, chitosan, alginic acid, aquogel and nano-dressing, etc.

Data Integration for Constructing Long-distance Medical Information Platform / 医疗卫生装备

Objective To study the structure and the use of the information sharing platform for long-distance medical information network in integrating long -distance medical information network, HIS, PACS system and other resources, thereby enhancing the quality of long -distance medical consultation. Methods The study was conducted by integrating hospital internal data resources, structuring information platform and standardizing consultation process. Results The information sharing platform was achieved based on long-distance medical information network, thus achieving the greatest degree of information sharing and raising the level of long-distance medical consultation.