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Objective:To retrospectively analyze the impact of adjuvant iodine-125( 125I)brachytherapy on postoperative recurrence and survival for patients with hepatocellular carcinoma (HCC) treated with partial hepatectomy with narrow resection margins. Methods:The data of 72 HCC patients who underwent partial hepatectomy with narrow resection margins from January 2011 to June 2015 at Weihai Municipal Hospital were analyzed retrospectively. The patients were divided into the adjuvant 125I brachytherapy group ( 125I group) ( n=36) and the control group ( n=36). The data of the two groups of patients were compared to study the factors influencing long-term survival outcomes and recurrence. Results:The follow-up time was (45.0±18.4) months. There were no deaths relating to 125I brachytherapy. The median recurrent free survival (RFS) was significantly longer in the 125I group than the control group (41.0 months vs 21.5 months, P<0.05). The 1-, 3- and 5-year RFS rates of the 125I group and the control group were 94.4%, 58.3%, 41.6% versus 86.1%, 33.3%, 25.0%, respectively ( P<0.05). The 1-, 3- and 5-year overall survival (OS) rates of the 125I group versus the control group were 97.2%, 69.4%, 52.8% versus 94.4%, 52.8%, 27.8%, respectively ( P<0.05). On multivariate analysis, 125I implantation was an independent factor affecting RFS and OS ( HR=2.112, 95% CI: 1.155-3.860, P<0.05; HR=2.492, 95% CI: 1.272-4.693, P<0.05). Conclusion:Adjuvant 125I brachytherapy was safe and effective for HCC patients with narrow resection margins after hepatectomy. It obviously reduced the tumor recurrence rate and prolonged the long-term RFS and OS.
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Objective To discuss the clinical effects of interferon combined with ganciclovir in treating children infectious mononucleosis(IM)related to EB virus.Methods 45 IM cases were distributed into study group with 25 cases and control group with 20 cases based on parents known and agreed.Children of two groups were both treated with traditional treatment and interferon,and children in study group were added treatment with ganciclovir.To separately observe the improvement and clinical effects of two groups.Results The time of hospital stay,normal body temperature returned,lymph nodes reduced,spleen retraction,liver retraction,angina relieve and abnormal lymphatic recovery of study group[(10.2 ±3.6)d,(3.2 ± 1.4)d,(6.7 ±2.2)d,(10.2 ±3.3)d,(8.3 ±2.7)d,(8.2 ±3.4)d,(9.4 ±3.2)d,were significantly less than control group(13.4 ±3.9)d,(5.6 ±2.3)d,(11.2 ±2.8)d,(12.1 ±3.2)d,(10.0 ± 1.8)d,(11.1 ±3.8)d,(12.1 ±3.5)d],(all P ＜0.05).The effective rate of study group 96％ was significantly higher than control group 80％(P ＜ 0.05).Conclusion It had good effects of interferon combined with ganciclovir in treating children infectious mononucleosis related to EB virus,which could improve the clinical effective rate and less the duration of adverse symptoms.
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Objective:To investigate whether CD3McAb activated killer(CD3AK)cells could induce apoptosis in HL 60 cells in serum free culture system.Methods:HL 60 cells were coincubated with CD3AK cells expanded in serum free medium,then apoptosis was assessed by means of morphological studies,DNA agarose gel electrophoresis and flow cytomether(FCM) analysis.Results:After 7 h of coincubation with CD3AK cells in serum free medium,HL 60 cells showed morphological features of apoptosis and typical DNA ladder on gel electrophoresis.FCM analysis showed that 24.59% cells were found to undergo apoptosis.Conclusion:CD3AK cells can induce apoptosis in HL 60 cells under serum free culture conditions.