ABSTRACT
Objective To understand the endemic situation of schistosomiasis after its transmission interruption in Baoying County,so as to provide the evidence for adjusting the prevention and control strategy. Methods The data of schistosomiasis surveillance in Baoying County from 1988 to 2015 were collected and retrospectively analyzed. Results The schistosomiasis surveillance has been established since it was interrupted in Baoying County in 1987. The total surveyed area with Oncomelania hupensis snails was 21 269.95 hm2,but no living snails were found. The number of schistosomiasis examinations of residents was 163 196 person?times,and 270 person?times were positive in serum test,26 person?times were positive in stool test. No positive cases were found since 1997. The number of schistosomiasis tests of livestock was 2 180 cattle?times but no infection was found. Conclusion No schistosome infected snails or livestock are founded in Baoying County for last 28 years,and no patients are founded for last 11 years. The effect of schistosomiasis control is steady.
ABSTRACT
Cell therapy has a very promising potential for end-stage liver diseases (ESLD).Fetal liver stem/progenitor cells (FLSPCs) have advantages of safety,high survival and proliferation rates,and a small volume,all which make them ideal for liver disease stem cell therapy.During the early phase of our study,we applied a three-step separation method to enrich FLSPCs and obtained a separation efficiency similar to that of the flow-cell sorting method.Additionally,using a fulminant hepatic failure model in rats,we have demonstrated that FLSPCs can contribute to morphological and functional recovery of the liver.This manuscript will discuss how FLSPCs can be induced to accurately differentiate into hepatocytes and cholangiocytes and how FLSPCs maintain self-renewal.The Notch signaling plays a critical role in regulating the differentiation and self-renewal of many types of stem cells.Our previous findings have shown that the Notch signaling plays an important role in FLSPCs differentiation into hepatocytes.Therefore,the Notch signaling might be involved in the differentiation and self-renewal of FLSPCs.We conducted a study on the regulatory effects and relative molecular mechanisms of the Notch signaling on FLSPCs and found the corresponding interfering target,which might become an index for the clinical application of FLSPCs.