Pregnancy complicated with severe special diseases in 2014-2016 in Shanghai:its risk management study / 上海预防医学

Objective To study the risk management of pregnancy with severe special diseases. Methods The relevant data on 181 women (< 28 weeks gestation) with severe special diseases reported from 2014 to 2016 in Shanghai city were analyzed retrospectively. Results The incidence of pregnancy with severe special diseases rose from 2014-2016, the incidence of 2016 was significantly higher than that of 2014 (P < 0.01).The average age of 181 pregnant women with severe special diseases was (29.06±5.41) years old, and pregnant women over 35 years of age accounted for 16.02%.The proportion of pregnant women (over 35) with severe special diseases in 2016 increased compared with the previous two years.Among 181 pregnant women with severe special diseases, the proportion of non-household registration people(76.80%) was higher than that of Shanghai household registered women(23.20%), the pregnant women who temporarily lived in Shanghai(residence time < 6 months) accounted for 35.91%.The top three diseases of 181 pregnant women with severe special diseases were pregnancy with cardiopathy, pregnancy with blood diseases and pregnancy with diseases of the immune system.Among the 181 pregnant women with severe special diseases, 47 cases received rescue of severe pregnant (259.67‰), which was significantly higher than the incidence of critically ill pregnant women in Shanghai during 2014-2016 (2.31‰, 3.12‰, 3.31‰ for three years respectively, and the average 2.89‰).The hospitalization expenses were lower if pregnancy terminated within 13 weeks gestation (P < 0.05). Conclusion To strengthen early intervention for pregnancy with severe specific diseases, for the purpose of ensuring the safety of mothers and infants, improving the quality of life for the pregnant women, reducing the burden on pregnancy and saving medical and health costs.To increase the risk awareness and intervention compliance of pregnant women with severe special diseases for the purpose of reducing maternal mortality.

Pregnancy complicated with severe special diseases in 2014-2016 in Shanghai:its risk management study / 上海预防医学

Objective To study the risk management of pregnancy with severe special diseases. Methods The relevant data on 181 women (< 28 weeks gestation) with severe special diseases reported from 2014 to 2016 in Shanghai city were analyzed retrospectively. Results The incidence of pregnancy with severe special diseases rose from 2014-2016, the incidence of 2016 was significantly higher than that of 2014 (P < 0.01).The average age of 181 pregnant women with severe special diseases was (29.06±5.41) years old, and pregnant women over 35 years of age accounted for 16.02%.The proportion of pregnant women (over 35) with severe special diseases in 2016 increased compared with the previous two years.Among 181 pregnant women with severe special diseases, the proportion of non-household registration people(76.80%) was higher than that of Shanghai household registered women(23.20%), the pregnant women who temporarily lived in Shanghai(residence time < 6 months) accounted for 35.91%.The top three diseases of 181 pregnant women with severe special diseases were pregnancy with cardiopathy, pregnancy with blood diseases and pregnancy with diseases of the immune system.Among the 181 pregnant women with severe special diseases, 47 cases received rescue of severe pregnant (259.67‰), which was significantly higher than the incidence of critically ill pregnant women in Shanghai during 2014-2016 (2.31‰, 3.12‰, 3.31‰ for three years respectively, and the average 2.89‰).The hospitalization expenses were lower if pregnancy terminated within 13 weeks gestation (P < 0.05). Conclusion To strengthen early intervention for pregnancy with severe specific diseases, for the purpose of ensuring the safety of mothers and infants, improving the quality of life for the pregnant women, reducing the burden on pregnancy and saving medical and health costs.To increase the risk awareness and intervention compliance of pregnant women with severe special diseases for the purpose of reducing maternal mortality.

Iridoid glycoside extraction technology and anti-thrombotic activity of Osmanthus fragrans seeds / 中草药

Objective: To optimize the extraction technology of two major iridoid glucosides (specnuezhenide and nuezhenoside G13) from four kinds of Osmanthus fragrans (OF) seeds, and to evaluate the anti-thrombotic activity of OF seeds. Methods: The orthogonal-test experiment was employed to optimize the parameters including ethanol concentration, liquid-material ratio, and extraction time for three extraction methods (ultrasonic extraction, reflux extraction, and microwave extraction). The extraction yield, content, and total peak area of iridoid glucosides were selected for weighted analysis to determine the best extraction method and technology. Additionally, an anti-thrombotic zebra fish model was established for biological evaluation of OF seeds. Results: Microwave extraction was the best method for iridoid glucosides extraction with the optimal conditions of ethanol concentration 55%, material-liquid ratio 1∶10, and microwave time 15 min. HPLC analysis showed that there was no significant difference in chemical composition among the four kinds of OF seeds. In zebra fish biological screening model, OF seeds displayed a weak inhibitory effect on the growth of thrombus and exhibited a pericardial edema effect in high dose-treated group. Conclusion: In this paper, extraction technology of two iridoid glucosides from four different kinds of OF seeds and preliminary anti-thrombotic activity evaluation of OF seeds were investigated. These results can provide the reference for further development and utilization of the agricultural waste of OF seeds.

Influence of pitavastatin on vascular endothelial function in young and middle-aged patients with hyperlipidemia complicated carotid plaques / 心血管康复医学杂志

Objective: To explore therapeutic effect of pitavastatin on young and middle-aged patients with hyperlipidemia complicated carotid plaques and its influence on vascular endothelial function. Methods: A total of 126 young and middle-aged patients with hyperlipidemia complicated carotid plaques [carotid intima-media thickness (IMT) ＞ 1. 5mm]were selected, and were randomly divided into no lipid lowering treatment group (n=62) and pitavastatin group (n=64). Flow-mediated dilation of brachial artery (FMD), carotid IMT and blood lipid levels before and 12 months after medication, and incidence rate of adverse events were recorded and compared between two groups. Results: Compare with before treatment and no lipid lowering treatment group after treatment, there was significant rise in FMD [(6. 70±2. 10) ％, (6. 60±2. 35) ％ vs. (8. 90±3. 60) ％], and significant reductions in levels of total cholesterol [(6. 05±1. 40) mmol/L, (5. 67±1. 90) mmol/L vs. (4. 05±1. 20) mmol/L], triglyceride [(2. 18± 0. 72) mmol/L, (2. 08±0. 68) mmol/L vs. (1. 77±0. 65) mmol/L]and low density lipoprotein cholesterol [(4. 65±1. 50) mmol/L, (4. 41±1. 36) mmol/L vs. (2. 01±1. 30) mmol/L]in pitavastatin group, P＜0. 05 or＜0. 01; there were no significant changes in IMT in two groups. No obvious adverse reaction was found in pitavastatin group. Conclusion: Pitavastatin can significantly improve lipid levels and vascular endothelial function in young and middle-aged patients with hyperlipidemia complicated carotid plaques.

Analysis of traditional Chinese medicine syndrome, traditional Chinese medicine and western medicine in 84 697 patients with coronary heart disease based on big data / 中国中药杂志

In order to understand the clinical characteristics of patients with coronary heart disease (CHD) in real world and provide reference for clinical prevention and treatment, this study analyzed informations of patient with CHD in hospital information system. Data from 17 national hospitals were collected. Select patients with coronaryheart disease in diagnosis of the first place in 17 hospitals, general informations and traditional Chinese medicine (TCM) syndrome, complications, medicine were analyzed using frequency method and association rules. This study included 84 697 patients with CHD, the majority of men and in the elderly. The average age of patients was 71 years. The proportion of men to women was about 1. 45: 1. Hospital stay time ranged from 8 to 14 d. The most common total hospitalization cost distribution was 5 000-20 000 RMB. Young patients have a rising trend year by year. The death of patients increased with increasing age. Common complications were hypertension, diabetes, cerebral infarction and hyperlipidemia, 57.24 percent of the CHD patient complicated with hypertension, 21.94 percent patients complicated with diabetes. Among TCM syndrome types, Qi-Yin deficiency and qi deficiency blood stasis were the most common syndromes. Blood stasis was the highest syndrome elements, accounted for 79.97%, followed by Qi deficiency, phlegm, Yin deficiency, and so on. The most common western medicine was aspirin, followed with isosorbide dinitrate, clopidogrel. The most common used traditional Chinese medicine was danhong injection, followed by shuxuetong injection. Combined with removing blood stasis drugs has been more common at present clinical treatment, there were 43.46 percent of patients combined with anti-platelet western drug and injection of removing blood stasis.

Preliminary study on integration of traditional Chinese medicine and western medicine in patients with coronary heart disease in real world / 中国中药杂志

<p><b>OBJECTIVE</b>Observe and analyze the informations of western medicine and traditional Chinese medicine in patients with coronary heart disease (CHD), in order to provide reference for clinical treatment.</p><p><b>METHOD</b>Select patients with CHD in diagnosis of the first place in 17 hospitals, drug informations of these patients were analyzed using frequency method and association rules.</p><p><b>RESULT</b>In 84 697 patients,there were 47 564 males and 32 882 females. The median age was 71 years old, 76 172 patients have medicine records, including 278 kinds of western medicine and 331 kinds of traditional Chinese medicine. Aspirin was the most common used western medicine (51 132 patients, 67.08%), followed by isosorbide dinitrate, clopidogrel etc. The most common used traditional Chinese medicine was danhong injection, followed by shuxuetong injection. After classified the drugs, at the forefront of western medicine were antiplatelet drugs, nitrates drugs, statins, beta blockers, calcium antagonists, ACEI; the most used in traditional Chinese medicine was injection of blood-activating and stasis-resolving, followed by oral preparations of blood-activating and stasis-resolving medicine, Fuzheng class oral medicine, purgation medicine etc. After association rules, combination therapy among western medicine was the most common, combination of western medicine with blood-activating and stasis-resolving was very commonly, especially antiplatelet drugs and nitrates drugs.</p><p><b>CONCLUSION</b>Western medicine in the treatment of patients with CHD was in accordance with the guidelines recommend, but with the lower utilization rate. Traditional Chinese medicine has become an important method for the treatment of CHD, promoting blood circulation and removing blood stasis is an important part of traditional Chinese medicine treatment in patients with CHD.</p>

DUOX2 gene mutation in patients with congenital goiter with hypothyroidism / 中华儿科杂志

<p><b>OBJECTIVE</b>To identify DUOX2 gene mutation in patients with congenital goiter with hypothyroidism.</p><p><b>METHOD</b>Five patients who had transit congenital hypothyroidism with goiter were enrolled. The exons of DUOX2 gene were amplified and sequenced.</p><p><b>RESULT</b>A heterozygous missense mutation C1329T in the exon 10 of the DUOX2 gene was found in one patient, predicted to result in a Tryptophan to Arginine substitution at codon 376. However no mutation was detected in the other patients.</p><p><b>CONCLUSION</b>p.Arg376Trp mutation in DUOX2 was found in newborns of congenital hypothyroidism. The alleles frequency of this mutation may contribute to the function loss of congenital hypothyroidism.</p>

Debating some issues on the national standard Standardized Manipulation of Acupuncture and Moxibustion, part 3: Auricular Acupuncture / 中国针灸

The main difficulties and disputable problems on develping the national standard Standardized Manipulation of Acupuncture and Moribustion, Part 3: Auricular Acupuncture are debated in this paper from the three aspects of its meaning, scientific basis and key point. The difficult points mainly include manipulation standandization of auricular acupuncture, basis and science of the standards stipulated, selection of technical terms and definition, and why only the four kinds of manipulations are used for auricular acupuncture. Finally, the authors suggest that the Standardized Manipulation of Acupuncture and Moxibustion, Part 3: Auricular Acupuncture needs further to be studied and improved.

A brief talk on characteristics of Japanese collateral puncture / 中国针灸

The characteristics of Japanese collateral puncture are expounded from history evolution and technical feature. The position of pricking blood and blood-letting volume for the three Japanese collateral puncture, Japanese collateral puncture at Jing-well points, at fine collaterals and at the skin are emphatically discussed and briefly compared with Chinese pricking blood therapy, so as to better develop the collateral puncture therapy.

Effect of sea food intake on the level of urinary iodine in women / 中国地方病学杂志

Objective To investigate the effect of seafood intake on the urinary iodine level in women for exploring an alternative to iodine supplementation.Methods Healthy pregnant women and non-pregnant women, aged 20～40 years,were selected during their health examination in local women'S health care in 2006.The types of seafood and its intake frequency were recorded from these women.and urine and kitchen salt samples were collected for iodine determination.Results A total of 198 women including 148 pregnant and 50 non-pregnant women were recmitod for this study;they had a median level of urine iodine of 87.51 mg/L.The median levels of urine iodine of83.49,91.52,166.45μg/L in three group women classified as hardly,seldom and often intake of see food showed significant difference(X2=6.202,P<0.05).Urine iodine level in non-pregnant women taking seafood (90.94μg/L)was higher than that in pregnant women(84.79μg/L),the difference being statistically significant (U=3318.00,P<0.05).The urine iodine in pregnant women with seldom intake of seafood(94.46 μg/L)was significantly higher than that in the hardly intake women(83.28 μg/L),the difference being statistically significant (U=1257.5,P<0.05).During late period of gestation,the urinary iodine in the women ofthree statUS of hardly. Seldom and often intake of seafood were 81.93,97.97 and 140.18 μg/L,respective,with significant differences among them.Conclusions A certain amount of seafood taken every week Can increase urine iodine levels,and a direct relationship Was observed.Therefore,we suggest that it is necessary to advocate taking seafood to pregnant women for prevention of cretinism,particularly in the air.as where iodized salt was difficult to implement.

Valsartan eluting-stents inhibited neointimal hyperplasia by decreasing collagen deposition in rabbits / 中华心血管病杂志

<p><b>OBJECTIVE</b>To assess the effect of valsartan eluting-stents on restenosis and collagen deposition in neointima hyperplasia in rabbits.</p><p><b>METHODS</b>Valsartan eluting-stents and the carrier eluting-stents were made with patented multi-layers coating techniques. Bare stents (n = 8), carrier eluting-stents (n = 8) and valsartan eluting-stents (n = 10) were implanted into rabbit abdominal aortas, respectively. Quantitive angiography (QA) was performed before, immediately post and 3 months after stents implantations to determine the diameter of aortas. Rabbits were killed 3 months post stents implantation and the cross sections of the stented vessels were analyzed for neointimal formation: luminal area (LA), neointimal area (NIA), inner elastic lumina area (IELA), the maximal inner-membrane thickness (MIT) and percent stenosis. MASSON and picrosirius red staining were performed to observe the collagen deposition in neointima analyzed.</p><p><b>RESULTS</b>The mean aortic diameters measured by QA at different time points were similar between the groups. LA was significantly larger (5 016 269 microm(2) +/- 207,934 microm(2) vs. 4,345,548 microm(2) +/- 125,822 microm(2) and 4,302,061 microm(2) +/- 167,952 microm(2), P < 0.01 vs. valsartan stents) while NIA (441,577 microm(2) +/- 74,099 microm(2) vs. 1,119,635 microm(2) +/- 163,503 microm(2) and 1,135,636 microm(2) +/- 136,555 microm(2)) and MIT (116 microm +/- 12 microm vs. 240 microm +/- 30 microm and 192 microm +/- 21 microm) as well as percent stenosis (8% +/- 2% vs. 20% +/- 2% and 21% +/- 2%) were significantly reduced in valsartan eluting-stents group compared to bare and carrier stents groups. MASSON and picrosirius red staining revealed rich type III collagen deposition in neointima and spare type I collagen patched around stents struts in bare and carrier stents groups and collagen deposition was rarely seen in neointima and stents struts in valsartan eluting-stents group.</p><p><b>CONCLUSION</b>Valsartan eluting-stents inhibited neointimal hyperplasia by decreasing collagen deposition.</p>