ABSTRACT
[Abstract] Objective To evaluate the effectiveness of chlorhexidine/silver sulfadiazine catheters vs. conventional standard catheters in the prevention of catheter-related bloodstream infections with bundles. Methods We searched the Cochrane Library, Embase, Medline, CINAHL and Web of Science databases from construction to March 2019 for randomized controlled trials to compare the use of chlorhexidine/silver sulfadiazine catheters and conventional standard catheters. Cochrane bias risk assessment tool was used to evaluate the included research, and the effective data was extracted. The set risk ratio (RR) was calculated with 95% confidence interval (CI), and the rate of CRBSI per 1000 catheter-days and bacterial colonization rate were measured. The primary outcome was CRBSI thousand day rate and the secondary outcome was bacterial colonization rate. The meta analysis was performed by R3.4.1 software. Results Seventeen trials included 4892 patients who received chlorhexidine/sulfadiazine silver coated catheters and conventional standard catheters were included. Compared with conventional standard catheters, chlorhexidine/ silver sulfadiazine catheters were associated with a lower incidence of catheter colonization (RR=0.55, 95%CI: 0.45-0.68, P=0.02). In addition, the the difference of the rate of CRBSI per 1000 catheter-days was not significant (RR=0.70, 95%CI: 0.48-1.02, P=0.32). Conclusion Compared with conventional standard catheters, the use of chlorhexidine/silver sulfadiazine-catheters with bundles can further reduce the incidence of catheter colonization, but does not reduce the rate of CRBSI per 1000 catheter-days.