Recommendation of Practical Learning Materials in Teaching Biochemistry / 中国生物化学与分子生物学报

The purpose of this paper is to share some practical learning materials with teachers engagedin biochemistry teaching. Students studying biochemistry can also use them directly. The materials includemultimedia such as the song “Biochemistry” and the video “The working principle of ATP synthase”, websites such as RCSB PDB protein structure database, software such as molecular imaging softwareRasmol, etc. Physical models such as the paper model of DNA double helix and the primary, secondaryand tertiary structures of tRNA are also introduced. The practicability of the materials is emphasized. Theapplication scenarios and the anticipated results of the materials are briefly described. Therecommendation levels are also denoted as stars.

Follow up of 16 cases with congenital toxoplasmosis treated with azithromycin / 中华儿科杂志

<p><b>OBJECTIVE</b>To study the therapeutic effects of azithromycin in treatment of congenital toxoplasmosis in children.</p><p><b>METHODS</b>Definite diagnosis of congenital toxoplasmosis was made on the basis of clinical manifestation combined with one or more positive results of the following laboratory tests and excluded other congenital infectious diseases: toxoplasma DNA (TOX-DNA), circulating toxoplasma antigen (TOX-CAG), and toxoplasma IgM antibody (TOX-IgM). All the patients were given oral azithromycin 10 mg/(kg.d) for 6 days followed by 8 days without medication (one course of treatment), and the regimen was persisted for 2 months and then another 2-month treatment was given at a 1-month interval. The authors continued to provide further treatment according to the state of the illness at one month interval. The patients received 2 to 8 (average 5) courses of treatment. The patients were followed-up for 2.5 to 5 (average 4) years.</p><p><b>RESULTS</b>The treatment was effective in all the patients and the patient's condition was improved. The authors repeated in 12 cases the four tests for toxoplasma (TOX-DNA, TOX-CAG, TOX-IgM, and TOX-IgG) 9 months to one and a half years after treatment. In 10 cases all these tests showed negative results, in 2 cases TOX-IgG was positive and in the other 4 cases symptoms disappeared.</p><p><b>CONCLUSION</b>The results of the study showed that oral azithromycin had significant therapeutic effects with little side effect and was well tolerated. Azithromycin may become an alternative therapy in treatment of congenital Toxoplasma gondii infection in children.</p>