Clinical feature of familial idiopathic basal ganglia calcification / 临床神经病学杂志

Objective To investigate the clinical features of familial idiopathic basal ganglia calcification (FIBGC).Methods Clinical data of 4 FIBGC patients from 2 families were analyzed retrospectively.Results The average age of 4 patients was(62.7 ±13.4)years old.The first symptom of 2 female patients was depression and schizophrenia, while 2 male patients displayed dementia and Parkinson's syndrome.Patients treated with vitamin D capsules,follow-up period for 3 to 6 months.All patients showed symptomatic improvement.Conclusions Clinical symptoms of FIBGC are complicated,and progressive development.The main symptom of female is mental symptoms, and male patients accompanied with dementia and dyskinesia.There is still no effective therapeutic plan for FIBGC.

Research Progress on the Risk Factors and Outcomes of Human Carotid Atherosclerotic Plaques / 中华医学杂志(英文版)

<p><b>OBJECTIVE</b>Atherosclerosis is an inflammatory process that results in complex lesions or plaques that protrude into the arterial lumen. Carotid atherosclerotic plaque rupture, with distal atheromatous debris embolization, causes cerebrovascular events. This review aimed to explore research progress on the risk factors and outcomes of human carotid atherosclerotic plaques, and the molecular and cellular mechanisms of human carotid atherosclerotic plaque vulnerability for therapeutic intervention.</p><p><b>DATA SOURCES</b>We searched the PubMed database for recently published research articles up to June 2016, with the key words of "risk factors", "outcomes", "blood components", "molecular mechanisms", "cellular mechanisms", and "human carotid atherosclerotic plaques".</p><p><b>STUDY SELECTION</b>The articles, regarding the latest developments related to the risk factors and outcomes, atherosclerotic plaque composition, blood components, and consequences of human carotid atherosclerotic plaques, and the molecular and cellular mechanisms of human carotid atherosclerotic plaque vulnerability for therapeutic intervention, were selected.</p><p><b>RESULTS</b>This review described the latest researches regarding the interactive effects of both traditional and novel risk factors for human carotid atherosclerotic plaques, novel insights into human carotid atherosclerotic plaque composition and blood components, and consequences of human carotid atherosclerotic plaque.</p><p><b>CONCLUSION</b>Carotid plaque biology and serologic biomarkers of vulnerability can be used to predict the risk of cerebrovascular events. Furthermore, plaque composition, rather than lesion burden, seems to most predict rupture and subsequent thrombosis.</p>

Effect of aluminum chloride on motor activity and species-typical behaviors in mice / 中华劳动卫生职业病杂志

<p><b>OBJECTIVE</b>To study the effect of aluminum chloride on motor and species-typical behaviors in mice.</p><p><b>METHODS</b>Male ICR mice were administered with drinking double distilled water only containing AlCl(3) (10, 50, 300 mg x kg(-1) x d(-1)), and control group with drinking double distilled water only for 100 days. Spontaneous activity test, grip strength, beam traversal, tightrope task, food hoarding, and nest construction were used to study the effect of chloride aluminum on motor and species-typical behaviors in mice.</p><p><b>RESULTS</b>The frequencies of spontaneous activity in low dose group, medium dose group and high dose group [(81.53 +/- 8.97), (71.67 +/- 8.37), (66.73 +/- 6.96) times respectively] were lower than that in control [(106.46 +/- 8.21) times] (P < 0.01), and were negatively correlated with doses (r(s) = -0.42, P < 0.01). Grip strength scores in medium dose group (19.19 +/- 1.48) and high dose group (13.36 +/- 1.46) respectively were lower than that in control (24.31 +/- 1.43) (P < 0.05, P < 0.01). Food hoarding was greater in high dose group [96.10 (90.20-99.00) g] than that in control group [84.00 (78.00-90.00) g (P < 0.05)]. The rest of parameters were of no statistical significance.</p><p><b>CONCLUSION</b>Subchronic exposure to AlCl(3) in mice may diminish motor activity and grip strength, but motor coordination was not impaired; alteration in food hoarding suggests damage to hippocampus cell.</p>

Effect of adult-onset hypothyroidism on neurogranin expression in hippocampus of adult male mice / 中华内分泌代谢杂志

Adult male Kunming mice were divided into normal control group,propylthiouracil(PTU) treated group and PTU+T_4 treated group.Neurogranin(Ng)protein expression in the hippocampus after 8 weeks was assayed by Western blotting and immunohistochemical method.Results showed that Ng protein was decreased in the hippocampus of male mice with adult-onset hypothyroidism,suggesting that decreased Ng,which is correctable by T_4,is involved in cognitive dysfunction in adult-onset hypothyroid male mice.