ABSTRACT
<p><b>OBJECTIVE</b>To observe the histological changes of gastric mucosa in patients with active gastric ulcer before and after treatment by Qifang Weitong Powder combined with omeprazole (QWP-Op).</p><p><b>METHODS</b>Sixty patients were equally randomized into the treated group and the control group. They were all treated in the 1st week by the Helicobacter pylori eradication triad regimen. From the 2nd to 6th week, the study group re-ceived QWP-Op therapy, and the control group was given Omeprazole alone.Biopsy specimens were obtained around ulcer area before and after treatment for histological observation on changes of gastric mucosa membrane.</p><p><b>RESULTS</b>The improvement of mucosal thickness and glandular morphology was better in the treated group than that in the control group (P <0.05).</p><p><b>CONCLUSION</b>QWP-Op therapy can improve the histological quality of ulcer healing and restore the morphological structure of gastric mucosa in patients with active gastric ulcer.</p>