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In this study, a new model of "Internet + PACD (namely, theoretical presentation, assimilatin, clinicopathological diagnosis and discussion)" was put forward in the online and offline course construction of surgical diagnostic pathology. and the teaching effect of this teaching model was evaluated through the performance evaluation and questionnaire survey. The results showed that the teaching model of "Internet + PACD" could not only significantly improve the performance of professional courses of students majoring in pathology, but also enhance their learning interest, confidence, competition and cooperation consciousness, which has been affirmed and recognized by students.
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The construction of Internet plus and big data pathology medical alliance platform is based on the Clinical Pathological Diagnosis Center of Qiqihar Medical University, on the basis of the digital pathological cloud platform provided by Jiangfeng biological assistance, relying on the medical development plan of Qi Medical Pathology diagnosis Center, cultivating the development concept of high, fine and sharp innovative pathological talents, and absorbing the leading figures of pathological diagnosis in various departments in China. From that, the real-time supervision and control of the diagnostic quality of Primary Pathological Diagnostic Unit can be established, the real-time, timely and accurate all-round training of Basic Pathological Diagnostic Technicians can be realized, and the level of basic pathological diagnosis can be quickly improved. A new training mode for pathology talents can perfectly fit with the big data medicine and artificial intelligence.
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The flipped class model is student-centered,which turns the traditional "teaching firstlearning behind" into the "learning first-teaching behind".The flipped class model can improve students' autonomous learning ability and other abilities.This article introduces the application of the flipped class in the course of medical immunology,including the course content selection,building QQ group learning platform,the production and release of independent learning resources,enactment of the task order and learning requirements,the design and implementation of classroom teaching activities and so on.The review and reflection of the formative assessment is also carried out.Through the reflection of the problems in the teaching,it is expected to lay the foundation for the promotion of the overturned class.
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Objective To investigate the effect of β-asarone on hippocampal neurons of experimental depression rats. Methods Eighty male adult SD rats were randomly divided into 4 groups, namely normal group, model group, fluoxetine(1.2 mg/kg) group and β-asarone (25 mg/kg) group. Depression rat model was established. The medication groups were given corresponding agents respectively. After treatment for 21 days, the number of apoptotic cells and the histological features in the hippocampus of rats were detected by flow cytometry and TUNEL, respectively. Results Compared with the normal group, typical apoptotic cells were found, apoptotic cell count and apoptotic rate were increased in the hippocampal CA3 and DG area of the model group (P<0.01). Compared with the model group, apoptotic cell count and apoptotic rate were decreased in the hippocampal area ofβ-asarone group and fluoxetine group (P<0.01). Conclusion The protective mechanism of β-asarone for the hippocampal cells of depression rats is probably associated with the reduction of the apoptosis of hippocampal neurons.
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0.05). Conclusions The expression of p16、 C-erbB-2 protein is correlated with gastric cancer and p16、C-erbB-2 protein can be used to evaluate the biological behavior and prognosis of gastric cancer.
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Objective To investigate cancer suppressor Genes p16, p15 in the brain gliomas expression and its relations with the gliomas pathology graduation and the malignant degree.Methods P16 and P15 protein expression level in human brain gliomas from 63 surgery specimens were assayed by immunobistochemical S-P method.Results P16, the P15 protein expression rate the brain gliomas pathology graduation assumes the inverse correlation with, also compared with the high malignant group the low malignant group (Ⅰ~Ⅱ level) (Ⅲ~Ⅳ level) has the remarkable difference (P
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Objective To observe the effects of Qifuyin on learning and memory ability and expression of somatostatin in hippocampus on Alzheimer’s disease (AD) rats. Methods SD rats were randomly divided into blank control group, sham operation control group, model group, donepezil group and Qifuyin group. The AD model was established by microinjection of A?1-42 into the bilateral hippocampus. The learning and memory ability of rats were evaluated with a series of tasks to find a hidden platform in Morris Water Maze. The expression levels of somatostatin in hippocampus were measured by immunohistochemical SP techniques. Results In the place navigation test, the mean escape latencies of the model group was obviously increased compared with sham operation control group (P
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Objective: To observe the effect of Tongluo Jiunao oral solution on learning and memory and the expression of AChE in hippocampus of AD rats induced by ?-amyloid1-40.Methods: 140 SD rats were divided into blank control group(normal group),pseudo-operation control group,negtive control group(model group),positive control group and experiment group(48、24、12mg?kg-1?d-1)at random.The model of AD were established by injecting ?-amyloid1-40 into bilateral hippocampus.After 4 weeks,Morris Water Maze was used to determine the ability of learning and memory.Immunohistochemical method and image analysis techniques were used to determine the expression of AChE in Hippocampus.Results: Compared with normal group,in place navigation test,the mean escape latencies of the model group increased obviously,and in spatial probe test,the frequency of passing through the platform of the model group decreased obviously(P