ABSTRACT
Objective@#To construct a nursing care service index system for postoperative ostomy patients with colorectal cancer based on Omaha system, which is used to guide nursing practice.@*Methods@#Using the Omaha system as the conceptual framework, using literature search method, expert group discussion, Delphi expert correspondence method, screening indicators to establish a system of postoperative care services for patients with colorectal cancer.@*Results@#The two rounds of expert letters asked that the effective recovery rate of the volume was 100%(28/28). The coefficient of expert authority of the two rounds of letters was 0.88 and 0.89 respectively, and the coordination coefficients of the expert opinions were 0.476 and 0.501 respectively. The finalized indicator system for care services includes 4 first-level indicators, 13 secondary indicators, and 61 third-level indicators.@*Conclusion@#The results of this study are scientific and reliable, and the formation of postoperative ostomy patients with colorectal cancerThe indicator system can provide a reference for clinical practice.
ABSTRACT
Objective:To construct a nursing care service index system for postoperative ostomy patients with colorectal cancer based on Omaha system, which is used to guide nursing practice.Methods:Using the Omaha system as the conceptual framework, using literature search method, expert group discussion, Delphi expert correspondence method, screening indicators to establish a system of postoperative care services for patients with colorectal cancer.Results:The two rounds of expert letters asked that the effective recovery rate of the volume was 100%(28/28). The coefficient of expert authority of the two rounds of letters was 0.88 and 0.89 respectively, and the coordination coefficients of the expert opinions were 0.476 and 0.501 respectively. The finalized indicator system for care services includes 4 first-level indicators, 13 secondary indicators, and 61 third-level indicators.Conclusion:The results of this study are scientific and reliable, and the formation of postoperative ostomy patients with colorectal cancerThe indicator system can provide a reference for clinical practice.
ABSTRACT
Objective To investigate the effect of a selective cyclooxygenase-2 inhibitor on tumor metastasis,tumor angiogenesis,and vascular endothelial growth factor(VEGF)of orthotopic implanted human gastric carcinoma in non.obesity diabetes(NOD)severe combined immune deficiency(SCID)mice.Methods Human gastric cancer SGC-7901 tissues were orthotopically implanted into the stomach of the NOD SCID mice.Forty mice were randomly divided into two groups which received either intravenous injections of 0.9% Nacl solution (0.9% NaCL solution group)or 50mg/kg.d Nimesulide(Nimesulide group)twice weekly for two weeks.Mice were sacrificed in the 5th week after implantation.Tissues from stomach and other organs were obtained for histopathologieal evaluation.The intratumoral microvessel density(MVD)and VEGF protein expression in tumor were evaluated by immunochemical method.Results The tumor metastasis rates were 18/20 in 0.9% Nacl solution group and 5/20 in Nimesulide group(P＜0.05).MVD was 9.5±2.9 in 0.9% NaCl solution group and 3.9±2.1 in Nimesulide group(P＜0.01).VEGF protein expression was 90% in 0.9%NaCl solution group and 25% in Nimesulide group(P＜0.01).Conclusions Nimesulide can inhibit the metastasis or gastric cancer through inhibiting tumor VEGF expression and tumor angiogenesis with no obvious anticoagulant activity.