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Mem. Inst. Oswaldo Cruz ; 99(3): 283-287, May 2004. tab, graf
Article in English | LILACS | ID: lil-361996

ABSTRACT

Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis whose interaction with the host may lead to a cell-mediated protective immune response. The presence of interferon-gamma is related to this response. With the purpose of understanding the immunological mechanisms involved in this protection, the lymphoproliferative response, IFN-gamma and other cytokines like interleukin (IL-5, IL-10), and tumor necrosis factor alpha (TNF-alfa) were evaluated before and after the use of anti-TB drugs on 30 patients with active TB disease, 24 healthy household contacts of active TB patients, with positive purified protein derivative (PPD) skin tests (induration > 10 mm), and 34 asymptomatic individuals with negative PPD skin test results (induration < 5 mm). The positive lymphoproliferative response among peripheral blood mononuclear cells of patients showed high levels of IFN-gamma, TNF-alfa, and IL-10. No significant levels of IL-5 were detected. After treatment with rifampicina, isoniazida, and pirazinamida, only the levels of IFN-gamma increased significantly (p < 0.01). These results highlight the need for further evaluation of IFN-gamma production as a healing prognostic of patients treated.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Antitubercular Agents , BCG Vaccine , Cytokines , Leukocytes, Mononuclear , Tuberculosis, Pulmonary , Antitubercular Agents , Biomarkers , Cytokines , Interferon-gamma , Interleukin-10 , Interleukin-5 , Tuberculosis, Pulmonary , Tumor Necrosis Factor-alpha
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