ABSTRACT
<p><b>OBJECTIVE</b>To investigate peripheral blood apelin levels in patients with acute ST-elevation myocardial infarction (STEMI) and their correlation with the one-year outcome of the patients.</p><p><b>METHODS</b>A total of 153 consecutive patients, including 93 with acute STEMI undergoing primary percutaneous coronary intervention (PCI), 30 with acute STEMI and 30 with stable angina all undergoing elective PCI, and 10 healthy control subjects were examined for peripheral blood apelin levels and clinical parameters. The composite endpoints (CEPs) were determined at the one year follow-up.</p><p><b>RESULTS</b>Apelin levels were significantly decreased in all the patients at admission, but increased following primary PCI. Apelin levels showed a negative correlation with glycosylated hemoglobin levels. At one year following PCI, the patients with a lower apelin level showed an increased risk for lowered left ventricular ejection fraction ratio, but further analysis failed to provide evidence that apelin levels were predictive of the one-year outcome.</p><p><b>CONCLUSION</b>Peripheral blood apelin levels might be useful for predicting the clinical outcomes of patients with acute STEMI.</p>
Subject(s)
Humans , Acute Disease , Apelin , Biomarkers , Blood , Case-Control Studies , Intercellular Signaling Peptides and Proteins , Blood , Myocardial Infarction , Blood , Diagnosis , Percutaneous Coronary Intervention , Prognosis , Ventricular Function, LeftABSTRACT
ObjectiveTo observe the relationship between the mean platelet volume (MPV) and stent thrombosis(ST) in patients after percutaneous coronary interventional procedures (PCI),to determine a concise and high-risk indicator to predict thrombosis in the patients after PCI.MethodsTo determine the MPV from 229 patients after PCI.The patients with MPV significantly increased were sekected as the observation group,the patients with normal MPV were selected as the control group.The stsituation in the two groups of ST was observed.The values in the two grups were analyzed.ResultsThe ST rate of control group was 1.22％,which was lower than that of the observation group(6.15％ )( x2 =4.02,P ＜ 0.05 ).ConclusionThe value of MPV increased was a risk factor for patients with thrombosis after PCI.Taking effective and timely adjustment of antithrombotic treatment options had an important clinical significance to prevent ST occur in patients after PCI.