ABSTRACT
Objective To investigate the clinical effect of Weining boil -free granule combined with auricular point pressing with bean in the treatment of chronic atrophic gastritis with liver -stomach disharmony .Methods 120 patients with chronic atrophic gastritis of liver -stomach disharmony were selected .They were randomly divided into treatment group (n=60) and control group (n=60) according to the digital table.The control group was treated with routine western medicine ,and the treatment group received Weining boil -free granule combined with auricular point pressing with bean .The clinical efficacies of the two groups was compared .Results The total effective rate of the treatment group was 95.0%,which was significantly higher than 76.6% of the control group,the difference was statistically significant(χ2 =8.29,P<0.05).Conclusion The effect of Weining boil -free granule combined with auricular point pressing with bean in the treatment of chronic atrophic gastritis with liver -stomach disharmony is better than that of the routine western medicine .
ABSTRACT
OBJECTIVE:To prepare Frovatriptan succinate film-coated tablet,and investigate its in vitro dissolution behavior. METHODS:Using lactose monohydrate,microcrystalline cellulose,dioxide,silica,sodium carboxymethyl starch and magnesium stearate as accessories,Frovatriptan succinate tablet was prepared. Using opadry premix spray-coating liquid,Frovatriptan succinate film-coated tablet was prepared. Single factor test was used,using moisture,angle of repose,rigidity,friability,disintegration time and dissolution rate as indexes,to screen the formulation;using dissolution degree as index,coating material dosage was screened. The dissolution curves in vitro of self-made tablets and imported tablets in water,0.1 mol/L HCL,pH of 5.5,6.8 phos-phate buffer solutions were compared. RESULTS:The optimal formulation of Frovatriptan succinate uncoated tablet was as follow as frovatriptan succinate 3.91 mg,lactose monohydrate 99.18 mg,microcrystalline cellulose 33.06 mg,magnesium stearate 1.40 mg,sodium carboxymethyl starch 1.05 mg,silica 1.40 mg;optimal coating weighed quality was 2.0%-4.0%. In the 4 mediums, the dissolution behavior of self-made tablets and imported tablets were similar. CONCLUSIONS:Frovatriptan succinate film-coated tablet is prepared successfully,and its in vitro dissolution behavior is similar to the imported preparations.