ABSTRACT
Objective: To investigate the association of maximum HR during the first day of intensive care unit [ICU] and mortality
Methods: Data of 850 patients over 45 years of age, who were hospitalized in ICU, was retrospectively analyzed. They were divided into two groups; Group-I, patients with maximum HR<100/min Group-II, patients with maximum HR >/= 100/min on first day. The groups were compared regarding age, sex, use of beta-blockers, use of inotropic and vasopressor drugs, hemodynamic parameters, anemia, mechanical ventilation, length of hospitalization [ICU and total], mortality [ICU and total], and CHARLSON and APACHE-II scores
Results: The mean age of patients was 63 +/- 12 years and 86% were after non-cardiac surgery. Maximum HR was 83 +/- 11 in Group-I and 115 +/- 14/min in Group-II [p=0.002]. Group-II patients had more frequent vasopressor and inotropic drugs usage, [p<0.001], anemia, mechanical ventilation [p<0.005], higher CHARLSON and APACHE-II scores, stayed longer in ICU and hospital, and had higher ICU and hospital mortality compared to group-I [p<0.05]. APACHE-II scores and maximum HR<100/min were independent variables predicting ICU mortality in multivariate logistic regression analysis whereas usage of beta-blockers was not
Conclusions: Our study showed that maximum HR less than100/minute during the first day of ICU is associated with decreased mortality in Intensive Care Unit