Expression of thyroglobulin antibody and thyroid peroxidase antibody in children with immune thrombocytopenia / 中国当代儿科杂志

OBJECTIVES@#To examine the expression of serum thyroglobulin antibody (TGAb) and thyroid peroxidase antibody (TPOAb) in children with immune thrombocytopenia (ITP).@*METHODS@#A total of 120 children with ITP who were admitted from October 2019 to October 2021 were enrolled as the ITP group. A total of 60 children without ITP were enrolled as the non-ITP group. According to the clinical classification of ITP, the children in the ITP group were further divided into a newly diagnosed ITP group, a persistent ITP group, and a chronic ITP group. The clinical data were compared between the ITP group and the non-ITP group and between the children with different clinical classifications of ITP. The expression levels of serum TGAb and TPOAb in children with ITP were measured and their association with the clinical classification of ITP was analyzed.@*RESULTS@#Compared with the non-ITP group, the ITP group had significantly lower levels of CD3+, CD4+, and platelet count (PLT) and significantly higher levels of CD8+, TGAb, and TPOAb (P<0.05). The children with chronic ITP had significantly lower levels of CD3+, CD4+, and PLT and significantly higher levels of CD8+, TGAb, and TPOAb than those with newly diagnosed ITP or persistent ITP (P<0.05). The logistic regression analysis showed that CD3+, CD4+, CD8+, TGAb, and TPOAb were the influencing factors for chronic ITP (P<0.05). A decision curve was plotted, and the results showed that TGAb combined with TPOAb within the high-risk threshold range of 0.0-1.0 had a net benefit rate of >0 in evaluating the clinical classification of ITP in children.@*CONCLUSIONS@#TGAb and TPOAb are abnormally expressed in children with ITP and are associated with the clinical classification of ITP in children.

Evaluation of efficacy and safety of loratadine in the treatment of childhood asthma / 中国当代儿科杂志

<p><b>OBJECTIVE</b>To evaluate the efficacy and safety of loratadine, a new generation of antihistaminics, in the treatment of childhood asthma.</p><p><b>METHODS</b>The papers related to loratadine treatment for childhood asthma were searched in the database of PubMed, MEDLINE, EMBASE, Cochrance, CNKI and CBMdisc (January 1990 to December 2010) electronically and manually. According to the Cochrane reviewer's handbook, the quality of the enrolled papers was assessed and a systematic review was performed.</p><p><b>RESULTS</b>A total of 179 papers were obtained. Eleven randomized controlled trials met the criteria and were included in this study. The 11 trials included 317 children with asthma: 159 cases in the loratadine treatment group and 158 cases in the control group. All included studies belonged to the B class according to the quality evaluation criteria. Meta analysis showed that the clinical symptoms were improved more, the forced expiratory volume in 1 second (FEV1) 4 and 8 weeks posttreatment and the peak expiratory flow rate (PEFR) 8 weeks posttreatment were higher in the loratadine treatment group than in the control group. The treatment-related adverse effects, fatigue, tachycardia and palpitation, occurred less in the loratadine treatment group compared with the control group.</p><p><b>CONCLUSIONS</b>Loratadine is safe and effective for the treatment of childhood asthma.</p>

Clinical efficiency of transcatheter occlusion of large patent ductus arteriosus in children / 中国当代儿科杂志

<p><b>OBJECTIVE</b>To study the clinical efficiency of transcatheter closure of large patent ductus arteriosus (PDA) using Amplatzer ductal occluder in children.</p><p><b>METHODS</b>A retrospective review was performed for 227 children with large PDA, including 63 cases with pulmonary artery hypertension. All cases accepted the transcatheter closure using Amplatzer ductal occluders. The median age of the patients was 3.2 years, and the median weight was 10.6 kg. The median of the narrowest diameter of arterial ducts was 5.7 mm.</p><p><b>RESULTS</b>Successful occlusion was achieved in 216 (95.2%) of the 227 cases. The mean pulmonary artery pressure in children with pulmonary artery hypertension decreased from 45±19 mm Hg before operation to 22±12 mm Hg after operation (P<0.05). In the 216 children achieving a successful occlusion, 109 children (50.5%) showed a complete occlusion immediately after operation by aortography and 181 children (83.8%) showed a complete occlusion by echocardiography 24 hrs after operation. No residual shunt was found in children who achieved a successful occlusion according to the results of echocardiography 6 and 12 months after operation.</p><p><b>CONCLUSIONS</b>The transcatheter occlusion of large PDA using Amplatzer ductal occluders is effective and safe in children.</p>