ABSTRACT
Proton pump inhibitors (PPI) are currently the most effective drugs for the treatment of acid related diseases. They are safe in short-term use, but can cause a series of security problems after long-term use. Hypomagnesemia caused by PPI is an important adverse drug reaction with reversible effect and has the following features: it only happens after long-term treatment with the extremely low occurrence rate; the proportion is higher in the elderly and female patients and usually independent of PPI dosage; magnesium supplementation is not effective for hypomagnesemia; the risk of hypomagnesemia increases when PPI is combined with diuretics, nephrotoxic drugs and drugs of reducing serum magnesium; H2-receptor antagonist is the best alternative of PPI. In this paper, we review hypomagnesemia induced by PPI.