ABSTRACT
Objective: To explore the feasibility of multicriteria synthesizing grading method using in the optimization of the fluidized granulation technology for Jianwei Xiaoshi Tablet (JXT), and to provide a reference for fluidized granulation technology to spread and apply in the pelletization of materials with strong stickiness. Methods: Using orthogonal design, the property parameters of granule and tablet were measured, and the best process parameters were optimized. Results: The optimal process parameters were as follows: The inlet air temperature was 55°C, the inlet pressure was 8 kPa, the spray pressure was 30 kPa, and the flow rate of the liquid was 1.0-2.5 mL/min. Conclusion: The multicriteria synthesizing grading method used in optimizing the fluidized granulation technology of JXT is stable and feasible, and provides theory evidence for improving the productivity and product quality.
ABSTRACT
To investigate such physical indexes as hygroscopicity, angle of repose, bulk density, fillibility of compression of mixed powder of directly compressed auxiliary materials and fermented cordyceps powder by using micromeritic study methods. The results showed that spray-dried lactose Flowlac100 and microcrystalline cellulose Avicel PH102 had better effect in liquidity and compressibility on fermented cordyceps powder than pregelatinized starch. The study on the impact of directly compressed auxiliary materials on the powder property of fermented cordyceps powder had guiding significant to the research of fermented cordyceps powder tablets, and could provide basis for the development of fermented cordyceps powder tablets.