Detection of hepatotoxic pyrrolizidine alkaloids in Ligularia Cass. with LC/MSn / 药学学报

<p><b>AIM</b>To detect the hepatotoxic pyrrolizidine alkaloids (HPA) in the genus Ligularia Cass..</p><p><b>METHODS</b>The alkaloid extracts of Ligularia plant materials were detected and analyzed by the method of combination of TLC, and LC/MSn.</p><p><b>RESULTS</b>Among 22 species of Ligularia Cass., HPA were detected in 18 species with LC/MSn, and no HPA was detected in the remaining 4 species.</p><p><b>CONCLUSION</b>HPA was first detected with LC/MSn in L. tongelensis and other 15 species of Ligularia Cass.; HPA from these plants should be isolated, separated and identified and it is necessary to study the activities and toxicities of the HPA. The types and kinds of HPA from different species and sources are different, they should be detected separately.</p>

Resource investigation and quality evaluation on wild Corydalis yanhusuo / 中国中药杂志

<p><b>OBJECTIVE</b>To study the resource and the quality of wild Corydalis yanhusuo distributed in China.</p><p><b>METHOD</b>Distribution was observed and samples of wild C. yanhusuo were collected and qualities were evaluated by determining six main alkaloids contained in the samples.</p><p><b>RESULT</b>The main distribution of wild Corydalis yanhusuo was in the hills around middle and lower reaches of Yangtze River. Its distributive areas were continuously decreasing. The alkaloids contents in the samples varied among different populations.</p><p><b>CONCLUSION</b>The alkaloids contents in wild populations of C. yanhusuo are diverse. The main kinds of alkaloids in some wild populations are higher than cultivated ones, which are valuable for breeding. The wild C. yanhusuo propagate well, however they are endangered due to environment problem, and should be protected.</p>