THE EFFECTS OF CIMETIDINE & RANITIDINE ON PENTO-BARBITAL SLEEPING TIMES IN RATS & MICE / 中国药理学通报

The pentobarbital sleeping times ( PST ) in rats and mice pretreated with ranitidine acutely or chronically do not differ significantly from the control groups. But the PST pretreated with cimetidine acutely and chronically both do prolong significantly in rats and mice. The blood pentobarbital concentration in the male rats pretreated with cimetidine chronically is significantly higher than the ranitidine and control groups. Close relationship between the PST and the blood pentobarbital concentration has been observed.