ABSTRACT
Objective To analysis of the causes and drug resistance characteristics in ICU patients with Citrobacter freundii hos‐pital infections ,for the future of clinical treatment and prevention of Citrobacter freundii infection provides the basis .Methods Col‐lected our hospitals from December 2011 to November 2014 clinical samples of ICU patients ,conventional isolation and culture of bacteria ,K‐B disk diffusion susceptibility test ,using Whonet5 .6 software analysis processing tentative data .Results Isolated from Critically ill patients Citrobacter freundii lower respiratory tract ,accounted for 64 .4% ;ESBLs producing high ,accounted for 35 .6% ;susceptibility testing showed the bacteria to imipenem ,meropenem ,nitrofurantoin ,kanamycin ,amikacin ,cefoperazone/sul‐bactam and piperacillin/tazobactam were more sensitive ,drug resistance rates were 3 .8% ,4 .5% ,8 .3% ,9 .1% ,17 .4% ,18 .1% and 22 .7% ,the rest of antimicrobial drug resistance rates more than 25 .0% .Conclusion Citrobacter freundii caused critically ill pa‐tients hospital infection have become increasingly serious ,lower respiratory tract was the main site of infection ,the bacteria used in the clinic for cephalosporin ,quinolones ,aminoglycosides and a variety of internal β‐lactam antibiotics were highly resistant ,clinicians should strengthen monitoring of drug resistance ,to reduce the resistant strains produced and spread within the hospital .
ABSTRACT
Objective Analysis isolated from ICU patients with severe types of different samples of Acinetobacter baumannii re‐sistance difference ,for effective prevention and control of Acinetobacter baumannii infection in ICU .Methods Retrospective analy‐sis of the college from January 2010 to December 2014 568 strains isolated from hospitalized ICU patients samples Acinetobacter baumannii clinical data .Results Isolated from ICU patients infected with Acinetobacter baumannii main source of sputum (60 .0% );drug sensitive test showed that Acinetobacter baumannii resistance to commonly used antimicrobial agents were generally multiple drug resistance ,the most sensitive to tigecycline ,cefoperazone/sulbactam ,resistance rate of less than 40 .0% ;isolated from sputum and sterile body fluid in Acinetobacter baumannii was generally higher than that of blood and urine to imipenem ,meropen‐em ,cefoperazone/sulbactam ,piperacillin/tazobactam ,ciprofloxacin ,levofloxacin ,amikacin resistance rate ,the difference was statis‐tically significant (P<0 .05) .Conclusion Acinetobacter baumannii multidrug resistant to commonly used antibiotics .In ICU differ‐ent specimen type drug resistance existence difference ,clinicians should strengthen the monitoring of drug resistance ,the treatment of the infection when the first choice of tigecycline ,Cefoperazone/sulbactam .
ABSTRACT
Objective Toinvestigatetheclinicalvalueofhumanneutrophillipocalin(HNL)detectioninthedifferentialdiagnosis of bacterial and viral infections of elderly patients with acute respiratory infection .Methods 142 elderly patients with respiratory infection were divided the bacteria group (96 cases) and the virus group (46 cases) according to their infections ,42 healthy people in the corresponding period were enrolled as the control group .Enzyme-linked immunosorbent assay and highly sensitive dry chemi-cal particles enhanced immune turbidity assay were employed to detect their blood HNL and C-reactive protein(CRP) ,respectively , and virus-specific antibodies detection were performed simultaneously .Results Compared the blood HNL ,CRP levels and their positive rates of patients in bacteria group with those in the virus group ,control group ,respectively ,differences showed statistically significant(P0 .05) .Antibiotic treatment before and 24 ,48 and 72 hours after ,the concentrations of HNL were (216 .8 ± 64 .1) , (192 .0 ± 41 .2) ,(158 .0 ± 54 .5) and (87 .0 ± 12 .4)μg/L ,respectively ,while those of CRP were (50 .9 ± 40 .9) ,(46 .2 ± 18 .3) , (39 .6 ± 9 .6) and (12 .6 ± 9 .8) mg/L ,respectively .Sensitivity ,specificity ,positive predictive value and negative predictive value of HNL detection were 90 .6% ,90 .9% ,91 .5% and 89 .9% ,respectively ,which were higher than those of CRP (88 .5% ,85 .2% , 86 .7% and 87 .2% ,respectively) ,with statistically significant difference(P<0 .05) .Conclusion NHL detection possesses impor-tant significance in differential diagnosis between bacterial and viral infections of elderly patients with acute respiratory infection .