ABSTRACT
<p><b>OBJECTIVE</b>To explore the distribution of monoamine oxidase A (MOA-A) EcoRV polymorphism in Shanghai Han population and its possible role in the risk for Parkinson's disease(PD).</p><p><b>METHODS</b>The MAO-A gene EcoRV polymorphism was detected with PCR-RFLP method in 110 PD patients and 182 healthy controls, furthermore, statistical analysis was performed to investigate association between EcoR V polymorphism and PD onset.</p><p><b>RESULTS</b>(1)Remarkable difference in MAO-A EcoR V polymorphic distribution has been observed between Shanghai Han population and that in North America. (2) Neither allelic frequency nor genotypic frequency in PD cases differs significantly from that in healthy controls regardless of data from male or female subclass.</p><p><b>CONCLUSION</b>There may be racial difference in the distribution of the human MAO-A EcoR V (C/T) polymorphism, but the present research does not support the association between this variant and susceptibility to PD in Chinese Han population of Shanghai area.</p>
Subject(s)
Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Alleles , China , DNA , Genetics , Metabolism , Deoxyribonucleases, Type II Site-Specific , Metabolism , Gene Frequency , Genotype , Monoamine Oxidase , Genetics , Parkinson Disease , Genetics , Polymorphism, GeneticABSTRACT
50 years old) (genotype GG 29 0∶28 2, GA 48 4∶52 4, AA 22 6∶19 4; allele G 53 2∶54 4) However, the distribution of parkin G/A genotype polymorphism was significantly different from that of Australian (PD: genotype ? 2=206 45; Han: GA 51 6%, Australian: GG 96 6% Control: ? 2=177 98; Han: GA 43 2%, Australian: GG 92 7 P