ABSTRACT
BACKGROUND@#Pneumonectomy and sleeve resection are routine operations for the treatment of central non-small cell lung cancer (NSCLC), but some patients suffered of central NSCLC, whose pulmonary function is too poor to tolerate pneumonectomy, or the tumor involves the bronchus and pulmonary artery extensively,it is hard to perform bronchovascular sleeve lobectomy. The aim of this study is to assess the feasibility of lung autotransplantation in the treatment of central NSCLC.@*METHODS@#The clinical data of 3 cases with central NSCLC treated by lung autotransplantation was reviewed from December 2016 to December 2018. One patient underwent double sleeve resection of left upper lobe with end-to-end anastomosis of the bronchus. Because the resection of the pulmonary artery was too long to perfrom a tension-free anastomosis, the inferior pulmonary vein was cut off, then the left lower lobe was moved up for an anastomosis of the inferior pulmonary vein and the stump of the superior pulmonary vein. In the other 2 cases, left pneumonectomy was performed directly, and the upper left lobe was excised in vitro. The lower left lobe was reset to the chest after trimming and flushing and then the bronchus, pulmonary artery and pulmonary vein were anastomosed in turn.@*RESULTS@#The average operation time was 333 min, the average time of vascular occlusion was 86 min, the average blood loss was 450 mL, and the average hospital stay was 18.7 d; Perioperative complications included a case of bronchial obstruction, which improved after sputum aspiration through bronchofibroscope. The average follow-up period was 20 mon; One case died of cancer, one case had recurrence of anastomotic stoma and brain metastasis, one case had 4R lymph node metastasis (stable condition after chemotherapy), and one case survived without recurrence.@*CONCLUSIONS@#For patients with central NSCLC with extensive tumor invasion, thus inability to tolerate sleeve resection or pneumonectomy, autologous lung transplantation can preserve lung function to the greatest extent with a complete tumor resection and improve postoperative quality of life.
ABSTRACT
AIM: This experiment was performed to evalu at e the significance of the expression of different types of protein kinase C (PKC ) in lung squamous cell carcinoma induced by methylcholanthrene(MAC).METHODS: Lung squamous cell carcinoma in Wistar rats was induced with MAC for 12 weeks. The stage of the cancer development was determined histop athologically. Immunohistochemistry method was used to study the expression of different types of protein kinase C ?,?,?,? in lung squamous cell carcinoma. RESULTS: The level of expression of PKC ? in lung squamous cel l car cinoma was significantly higher than that in peripheral lung tissues and normal lung tissues (24.08%?2.93%,5.00%?2.10%,1.96%?0.29%,respectively. P
ABSTRACT
The change of plasma TXB_2 and 6-Keto-PGF_1? which were stable metabolites of TXA_2 and PGI_2 respectively were observed in arterial blood of SHR and WKY and in different ages of SHR. The 6-Keto/TXB_2 ratios were computed. The results showed that TXB2 concentration of arterial blood were significantly higher in SHR than in WKY(1217.9?298.5Pg/ml vs 207.1?59.8Pg/ml, P